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儿童生长激素治疗:必要还是设计疗法?

Growth hormone use in children: necessary or designer therapy?

机构信息

Loyola University New Orleans School of Nursing, New Orleans, LA 70118, USA.

出版信息

J Pediatr Health Care. 2011 Jan-Feb;25(1):24-30. doi: 10.1016/j.pedhc.2010.03.005. Epub 2010 Apr 27.

DOI:10.1016/j.pedhc.2010.03.005
PMID:21147404
Abstract

Society often rewards the beautiful, the smart, and the intelligent. The possibility that children with idiopathic short stature (ISS) will sustain psychological damage as a result of ridicule from their peers is a concern. The desire for children to become tall adults provides a difficult quandary for parents and caregivers. Growth hormone (GH) treatment in children requires subcutaneous injections six to seven times weekly. The cost of treating with GH can be more than $52,000, and many third-party payers do not cover the cost of GH treatment. Research to date would indicate that while the administration of GH may improve final adult height in children with ISS, children treated with GH will remain short when compared with peers. More research is needed to study whether the administration of GH is beneficial for children with ISS. This article will discuss ISS and the use of GH in children.

摘要

社会通常会奖励美丽、聪明和智慧的人。患有特发性身材矮小症(ISS)的儿童可能会因为受到同龄人的嘲笑而遭受心理伤害,这令人担忧。父母和照顾者都希望孩子能长成高大的成年人,这让他们陷入了两难的困境。生长激素(GH)治疗需要每周进行六到七次皮下注射。GH 治疗的费用可能超过 52000 美元,许多第三方支付者都不承担 GH 治疗的费用。迄今为止的研究表明,尽管生长激素的使用可能会改善 ISS 儿童的最终成年身高,但与同龄人相比,接受 GH 治疗的儿童仍然矮小。还需要更多的研究来研究生长激素对 ISS 儿童是否有益。本文将讨论 ISS 和儿童生长激素的使用。

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Growth hormone use in children: necessary or designer therapy?儿童生长激素治疗:必要还是设计疗法?
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Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS).特发性身材矮小(ISS)生长激素(GH)治疗中胰岛素样生长因子I(IGF-I)的测定。
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引用本文的文献

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Parents' concerns regarding the growth characteristics of their adolescents: a qualitative inquiry in Iran.父母对其青少年生长特征的担忧:伊朗的一项定性研究
Int J Qual Stud Health Well-being. 2018 Dec;13(1):1453179. doi: 10.1080/17482631.2018.1453179.
2
Growth Hormone Utilization Review in a Pediatric Primary Care Setting.儿科初级保健环境中生长激素使用情况综述
J Res Pharm Pract. 2017 Jan-Mar;6(1):40-43. doi: 10.4103/2279-042X.200989.