Jang Wonhee, Gomer Richard H
Department of Life Science, Dongguk University, 3-26 Pil-dong, Jung-gu, Seoul 100-715, South Korea.
Eukaryot Cell. 2011 Feb;10(2):150-5. doi: 10.1128/EC.00219-10. Epub 2010 Dec 10.
Much remains to be understood about how a group of cells break symmetry and differentiate into distinct cell types. The simple eukaryote Dictyostelium discoideum is an excellent model system for studying questions such as cell type differentiation. Dictyostelium cells grow as single cells. When the cells starve, they aggregate to develop into a multicellular structure with only two main cell types: spore and stalk. There has been a longstanding controversy as to how a cell makes the initial choice of becoming a spore or stalk cell. In this review, we describe how the controversy arose and how a consensus developed around a model in which initial cell type choice in Dictyostelium is dependent on the cell cycle phase that a cell happens to be in at the time that it starves.
关于一群细胞如何打破对称性并分化为不同细胞类型，仍有许多有待了解之处。简单真核生物盘基网柄菌是研究诸如细胞类型分化等问题的优秀模型系统。盘基网柄菌细胞以单细胞形式生长。当细胞饥饿时，它们聚集形成一个仅具有两种主要细胞类型的多细胞结构：孢子和柄细胞。关于细胞如何做出成为孢子或柄细胞的初始选择，长期以来一直存在争议。在这篇综述中，我们描述了争议是如何产生的，以及围绕一个模型如何形成了共识，该模型认为盘基网柄菌中细胞类型的初始选择取决于细胞在饥饿时所处的细胞周期阶段。
