Kothari Mihir T, Turakhia Jinesh K, Vijayalakshmi Perumalsamy, Karthika Arumugam, Nirmalan Praveen K
Am Orthopt J. 2003;53:121-6. doi: 10.3368/aoj.53.1.121.
To determine the usefulness of the Brückner test as a screening tool for detection of amblyogenic factors in developing countries.
A double blind prospective study of 101 children aged 1 to 16 years attending the pediatric ophthalmology department of a tertiary eye care center. A trained optometrist masked to clinical findings of the subject performed the Brückner test in a dark room using a direct ophthalmoscope and compared differences in brightness of the pupillary reflex of both eyes. Subsequently, subjects underwent a complete ophthalmic examination by a pediatric ophthalmologist masked to the results of the Brückner test.
The optometrist identified 39 subjects as Brückner test positive and 62 as Brückner test negative. On clinical examination, 12 subjects had anisometropia of ≥1D and 20 subjects had manifest deviation of >4(Δ). The sensitivity of the Brückner test was 87.5% and specificity 84.1%; the positive (PPV) and negative predictive (NPV) value was 71.8% and 93.6%. The false positive and false negative rates were 28.2% and 6.5%.
Although imperfect, the Brückner test may be a low cost alternative to either screening with photo screener or to no screening for amblyogenic factors in developing countries.
确定布吕克纳试验作为发展中国家检测致弱视因素筛查工具的实用性。
对一家三级眼科护理中心儿科眼科门诊的101名1至16岁儿童进行双盲前瞻性研究。一名对受试者临床检查结果不知情的训练有素的验光师在暗室中使用直接检眼镜进行布吕克纳试验，并比较双眼瞳孔反射亮度的差异。随后，由一名对布吕克纳试验结果不知情的儿科眼科医生对受试者进行全面眼科检查。
验光师将39名受试者判定为布吕克纳试验阳性，62名判定为布吕克纳试验阴性。临床检查发现，12名受试者有≥1D的屈光参差，20名受试者有>4(Δ)的明显斜视。布吕克纳试验的敏感性为87.5%，特异性为84.1%；阳性预测值（PPV）和阴性预测值（NPV）分别为71.8%和93.6%。假阳性率和假阴性率分别为28.2%和6.5%。
尽管存在不足，但在发展中国家，布吕克纳试验可能是一种低成本的替代方法，可用于替代使用照片筛查仪进行筛查或不进行致弱视因素筛查。
