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Computational modelling of lung injury: is there potential for benefit?肺部损伤的计算建模:是否有潜在益处?
Philos Trans R Soc Lond B Biol Sci. 2011 Jan 27;366(1562):300-5. doi: 10.1098/rstb.2010.0250.
2
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本文引用的文献

1
The epidemiology of blast lung injury during recent military conflicts: a retrospective database review of cases presenting to deployed military hospitals, 2003-2009.爆炸肺损伤在近期军事冲突中的流行病学:2003-2009 年部署军事医院收治病例的回顾性数据库研究。
Philos Trans R Soc Lond B Biol Sci. 2011 Jan 27;366(1562):291-4. doi: 10.1098/rstb.2010.0251.
2
Indices of pulmonary oxygenation in pathological lung states: an investigation using high-fidelity, computational modelling.病理性肺状态下的肺氧合指标:一项使用高保真计算模型的研究
Br J Anaesth. 2009 Aug;103(2):291-7. doi: 10.1093/bja/aep140. Epub 2009 Jun 18.
3
Simulation of blast-induced early-time intracranial wave physics leading to traumatic brain injury.导致创伤性脑损伤的爆炸诱导早期颅内波物理模拟。
J Biomech Eng. 2009 Jun;131(6):061007. doi: 10.1115/1.3118765.
4
Injuries from explosions: physics, biophysics, pathology, and required research focus.爆炸所致损伤:物理学、生物物理学、病理学及所需的研究重点。
J Trauma. 2009 May;66(5):1468-77; discussion 1477. doi: 10.1097/TA.0b013e3181a27e7f.
5
Computational biology - modeling of primary blast effects on the central nervous system.计算生物学——原发性爆炸对中枢神经系统影响的建模
Neuroimage. 2009 Aug;47 Suppl 2:T10-20. doi: 10.1016/j.neuroimage.2009.02.019. Epub 2009 Feb 24.
6
Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients.血浆与血小板与红细胞比值升高可改善466例大量输血的 civilian 创伤患者的预后。 (注:这里“civilian”结合语境推测可能是“平民”,但从医学专业角度看这个词在这个语境不是非常准确的医学术语表述,可能原文有误或有特定背景含义)
Ann Surg. 2008 Sep;248(3):447-58. doi: 10.1097/SLA.0b013e318185a9ad.
7
Warm fresh whole blood transfusion for severe hemorrhage: U.S. military and potential civilian applications.用于严重出血的温热新鲜全血输注:美国军方及潜在的民用应用
Crit Care Med. 2008 Jul;36(7 Suppl):S340-5. doi: 10.1097/CCM.0b013e31817e2ef9.
8
Primary blast injury: update on diagnosis and treatment.原发性冲击伤:诊断与治疗的最新进展
Crit Care Med. 2008 Jul;36(7 Suppl):S311-7. doi: 10.1097/CCM.0b013e31817e2a8c.
9
Combat damage control surgery.战斗损伤控制手术
Crit Care Med. 2008 Jul;36(7 Suppl):S304-10. doi: 10.1097/CCM.0b013e31817e2854.
10
Damage control resuscitation: a sensible approach to the exsanguinating surgical patient.损伤控制复苏:对外科大出血患者的明智处理方法。
Crit Care Med. 2008 Jul;36(7 Suppl):S267-74. doi: 10.1097/CCM.0b013e31817da7dc.

肺部损伤的计算建模:是否有潜在益处?

Computational modelling of lung injury: is there potential for benefit?

机构信息

Division of Anaesthesia and Intensive Care, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK.

出版信息

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 27;366(1562):300-5. doi: 10.1098/rstb.2010.0250.

DOI:10.1098/rstb.2010.0250
PMID:21149367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3013438/
Abstract

State-of-the-art medical care of the victims of current conflicts is generating large quantities of quality clinical data as a by-product. Observational research based on these data is beginning to have a profound influence on the clinical management of both military and civilian trauma patients. Computational modelling based on these datasets may offer the ability to investigate clinical treatment strategies that are practically, ethically or scientifically impossible to investigate on the front line. This article reviews the potential of this novel technology to aid development of treatment for blast lung and other unresolved medical scenarios.

摘要

目前的冲突中,先进的医疗手段在救治受害者的同时,也产生了大量高质量的临床数据。基于这些数据的观察性研究开始对军事和民用创伤患者的临床管理产生深远影响。基于这些数据集的计算建模可能提供一种能力,以研究在前线实际、伦理或科学上不可能进行的临床治疗策略。本文回顾了这项新技术在辅助治疗爆震肺等未解决的医疗情况方面的潜力。