Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, and Cardiovascular Center, Guro Hospital, Seoul, Korea.
J Nucl Med. 2011 Jan;52(1):10-7. doi: 10.2967/jnumed.110.080838. Epub 2010 Dec 13.
We examined the severity of vascular inflammation in healthy individuals without hyperlipidemia but with elevated high-sensitivity C-reactive protein (hsCRP) using 18F-FDG PET, which is a promising imaging technique for the assessment of vascular inflammation within atherosclerotic plaques.
Vascular inflammation in the carotid arterial wall, represented as the target-to-background ratio (TBR), was measured using 18F-FDG PET in 120 healthy subjects without a history of cardiovascular diseases.
Subjects with high hsCRP (≥2 mg/L) and low low-density lipoprotein cholesterol (LDL-C) (<130 mg/dL) levels had a significantly higher maximum TBR than did those with low hsCRP (<2 mg/L) and low LDL-C levels (<130 mg/dL) or low hsCRP (<2 mg/L) and high LDL-C levels (≥130 mg/dL) (1.29±0.13, 1.12±0.10, and 1.16±0.05, respectively), even though there were no significant differences in the carotid intima-media thickness. The maximum TBR values had the strongest positive correlation with hsCRP level among the various cardiovascular risk factors (r=0.68, P<0.01). However, other emerging inflammatory markers such as lipoprotein-associated phospholipase A(2) or monocyte chemoattractant protein-1 were not coherently associated with TBR values. Multiple stepwise regression analyses showed that hsCRP and diastolic blood pressure were independent decisive factors for maximum TBR, whereas age, diastolic blood pressure, and LDL-C were factors that determined the maximum intima-media thickness.
Vascular inflammation measured using 18F-FDG PET was increased in healthy individuals without hyperlipidemia but with elevated hsCRP.
我们使用 18F-FDG PET 检查了无高血脂但高敏 C 反应蛋白（hsCRP）升高的健康个体的血管炎症严重程度，该方法是评估动脉粥样斑块内血管炎症的一种有前途的影像学技术。
通过 18F-FDG PET 测量 120 例无心血管疾病史的健康个体颈动脉壁的血管炎症，以血管炎症程度（代表为靶/背景比（TBR））来衡量。
hsCRP 较高（≥2 mg/L）和 LDL-C 较低（<130 mg/dL）的患者的最大 TBR 显著高于 hsCRP 较低（<2 mg/L）和 LDL-C 较低（<130 mg/dL）或 hsCRP 较低（<2 mg/L）和 LDL-C 较高（≥130 mg/dL）的患者（分别为 1.29±0.13、1.12±0.10 和 1.16±0.05），尽管颈动脉内膜中层厚度没有差异。最大 TBR 值与各种心血管危险因素中 hsCRP 水平呈最强正相关（r=0.68，P<0.01）。然而，其他新兴炎症标志物，如脂蛋白相关磷脂酶 A2 或单核细胞趋化蛋白-1 与 TBR 值并不一致。多元逐步回归分析显示，hsCRP 和舒张压是最大 TBR 的独立决定因素，而年龄、舒张压和 LDL-C 是最大内膜中层厚度的决定因素。
无高血脂但 hsCRP 升高的健康个体中，使用 18F-FDG PET 测量的血管炎症增加。
