Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Heart and Vascular Center, Semmelweis University, Gaál József street 9, Budapest, 1122, Hungary.
Curr Cardiol Rep. 2018 Feb 12;20(2):11. doi: 10.1007/s11886-018-0953-3.
With this review, we aim to summarize the role of positron emission tomography (PET) and near-infrared fluorescence imaging (NIRF) in the detection of atherosclerosis.
F-FDG is an established measure of increased macrophage activity. However, due to its low specificity, new radiotracers have emerged for more specific detection of vascular inflammation and other high-risk plaque features such as microcalcification and neovascularization. Novel NIRF probes are engineered to sense endothelial damage as an early sign of plaque erosion as well as oxidized low-density lipoprotein (oxLDL) as a prime target for atherosclerosis. Integrated NIRF/OCT (optical coherence tomography) catheters enable to detect stent-associated microthrombi. Novel radiotracers can improve specificity of PET for imaging atherosclerosis. Advanced NIRF probes show promise for future application in human. Intravascular NIRF might play a prominent role in the detection of stent-induced vascular injury.
本文旨在总结正电子发射断层扫描（PET）和近红外荧光成像（NIRF）在动脉粥样硬化检测中的作用。
18F-FDG 是一种公认的巨噬细胞活性增加的测量方法。然而，由于其特异性低，出现了新的放射性示踪剂，用于更特异性地检测血管炎症和其他高危斑块特征，如微钙化和新生血管形成。新型 NIRF 探针被设计用于感知内皮损伤，这是斑块侵蚀的早期迹象，以及氧化低密度脂蛋白（oxLDL），这是动脉粥样硬化的主要靶点。集成的 NIRF/OCT（光学相干断层扫描）导管可用于检测支架相关的微血栓。新型放射性示踪剂可提高 PET 成像动脉粥样硬化的特异性。先进的 NIRF 探针有望在未来应用于人体。血管内 NIRF 可能在检测支架诱导的血管损伤方面发挥突出作用。
