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果蝇翅成虫盘中转谷氨酰胺酶的过表达诱导了额外翅横脉表型。

Overexpression of transglutaminase in the Drosophila wing imaginal disc induced an extra wing crossvein phenotype.

作者信息

Ichikawa Akira, Yamada Ayako, Sakamoto Harunobu, Umehara Masaru, Yoshioka Yasuhide, Yamaguchi Masamitsu, Ikura Koji

机构信息

Department of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan.

出版信息

Biosci Biotechnol Biochem. 2010;74(12):2494-6. doi: 10.1271/bbb.100449. Epub 2010 Dec 7.

DOI:10.1271/bbb.100449
PMID:21150110
Abstract

To determine the roles of Drosophila transglutaminase-A (dTG-A), we examined a phenotype induced through ectopic expression of dTG-A. Overexpression of dTG-A in the wing imaginal disc induced an extra wing crossvein phenotype. This phenotype was suppressed by crossing with epidermal growth factor receptor (Egfr) signaling pathway mutant flies. These results indicate that this phenotype, induced by dTG-A, is related to enhancement of the Egfr signaling pathway.

摘要

为了确定果蝇转谷氨酰胺酶-A（dTG-A）的作用，我们检测了通过dTG-A异位表达诱导的一种表型。在翅成虫盘过度表达dTG-A诱导了额外翅横脉表型。通过与表皮生长因子受体（Egfr）信号通路突变果蝇杂交，这种表型受到了抑制。这些结果表明，由dTG-A诱导的这种表型与Egfr信号通路的增强有关。

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引用本文的文献

1
The developing wing crossvein of Drosophila melanogaster: a fascinating model for signaling and morphogenesis.果蝇发育中的翅横脉：信号转导和形态发生的迷人模型。
Fly (Austin). 2022 Dec;16(1):118-127. doi: 10.1080/19336934.2022.2040316.
2
TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations.TG-A转谷氨酰胺酶通过一种不依赖高尔基体的非常规机制分泌，该机制涉及外泌体和两种类型的脂肪酰化。
J Biol Chem. 2017 Jun 23;292(25):10723-10734. doi: 10.1074/jbc.M117.779710. Epub 2017 May 5.
3
Inhibition of transglutaminase exacerbates polyglutamine-induced neurotoxicity by increasing the aggregation of mutant ataxin-3 in an SCA3 Drosophila model.
在SCA3果蝇模型中，转谷氨酰胺酶的抑制通过增加突变型ataxin-3的聚集而加剧了多聚谷氨酰胺诱导的神经毒性。
Neurotox Res. 2015 Apr;27(3):259-67. doi: 10.1007/s12640-014-9506-8. Epub 2014 Dec 11.