Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Fly (Austin). 2022 Dec;16(1):118-127. doi: 10.1080/19336934.2022.2040316.
The wing has been used as a model for studying tissue growth, morphogenesis and pattern formation. The wing veins of are composed of two distinct structures, longitudinal veins and crossveins. Although positional information of longitudinal veins is largely defined in the wing imaginal disc during the larval stage, crossvein primordial cells appear to be naive until the early pupal stage. Here, we first review how wing crossveins have been investigated in the past. Then, the developmental mechanisms underlying crossvein formation are summarized. This review focuses on how a conserved trafficking mechanism of BMP ligands is utilized for crossvein formation, and how various co-factors play roles in sustaining BMP signalling. Recent findings further reveal that crossvein development serves as an excellent model to address how BMP signal and dynamic cellular processes are coupled. This comprehensive review illustrates the uniqueness, scientific value and future perspectives of wing crossvein development as a model.
翅膀被用作研究组织生长、形态发生和模式形成的模型。 的翅膀脉由两个不同的结构组成，即纵脉和横脉。尽管在幼虫阶段，翅膀的想象盘已经在很大程度上确定了纵脉的位置信息，但横脉原基细胞在早期蛹期之前似乎是幼稚的。在这里，我们首先回顾一下过去是如何研究翅膀横脉的。然后，总结了横脉形成的发育机制。这篇综述主要关注保守的 BMP 配体运输机制如何用于横脉形成，以及各种共因子如何在维持 BMP 信号中发挥作用。最近的发现进一步表明，横脉发育是解决 BMP 信号和动态细胞过程如何偶联的一个很好的模型。这篇全面的综述说明了翅膀横脉发育作为模型的独特性、科学价值和未来前景。
