[苯佐卡因对大鼠急性炎症及体外前列腺素合成酶活性的影响]
[The effect of benzofurocaine on acute inflammation in rats and on the activity of prostaglandin synthetase in vitro].
作者信息
Stepaniuk G I, Stoliarchuk A A, Mevkh A T, Igumnova N D
出版信息
Farmakol Toksikol. 1990 Mar-Apr;53(2):60-2.
PMID:2115012
Abstract
Benzofurocaine similarly to ortophen (voltaren) causes dose-dependent suppression of acute inflammatory reactions induced in rats by carragheenin, serotonin and histamine, protects animals from absolutely lethal dose of cellulose sulphate. When administered in a dose of 0.79 X 10(-3) M, benzofurocaine exerts no effect on the activity of prostaglandin synthetase.
摘要
苯并呋喃卡因与奥拓芬（扶他林）类似，能剂量依赖性地抑制角叉菜胶、血清素和组胺在大鼠体内诱导的急性炎症反应，保护动物免受硫酸纤维素的绝对致死剂量的影响。当以0.79×10⁻³M的剂量给药时，苯并呋喃卡因对前列腺素合成酶的活性没有影响。
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