Muratov V K, Mevkh A T, Igumnova N D, Churiukanov V V, Varfolomeev S D
Farmakol Toksikol. 1987 Jan-Feb;50(1):46-9.
A combined effect on the irreversible inhibitor aspirin and fast reversible inhibitors ibuprofen, naproxen and sodium salicylate on prostaglandin-H-synthetase was studied on microsomal fractions from ram vesicular glands. The fast reversible inhibitors were shown to bind to prostaglandin-H-synthetase at the same site as aspirin and thereby to protect the enzyme against irreversible inactivation by aspirin.
研究了不可逆抑制剂阿司匹林与快速可逆抑制剂布洛芬、萘普生和水杨酸钠对来自公羊精囊微粒体部分的前列腺素-H-合成酶的联合作用。结果表明，快速可逆抑制剂与阿司匹林在前列腺素-H-合成酶的同一部位结合，从而保护该酶不被阿司匹林不可逆失活。
