Fondazione GB Bietti, IRCCS, Roma, Italy.
Ophthalmologica. 2011;225(3):155-60. doi: 10.1159/000320340. Epub 2010 Dec 9.
BACKGROUND/AIM: To evaluate if retinal sensitivity values obtained with a dedicated (screening) device can be used to functionally identify early and intermediate age-related macular degeneration (ARMD).
A fully automatic fundus perimeter combined with an image-stabilized scanning laser ophthalmoscope was used in 200 ARMD patients (319 eyes) in 5 study sites. The age-matched control group consisted of 200 normals. Sensitivity point values (S values), mean retinal sensitivity, number of points below 24 dB (K value, cutoff for normal values) and fixation stability were recorded.
Of 319 eyes, 164 were classified as early (AREDS 2) and 155 as intermediate (AREDS 3) ARMD. Mean retinal sensitivity was significantly reduced in ARMD patients versus normals (p < 0.001). K values were different between normals and ARMD patients (p < 0.001). Fixation stability did not differ between early and intermediate ARMD patients.
Macular sensitivity is reduced in patients with early and intermediate ARMD when compared to age-matched normals. These changes may be detected with a screening device.
背景/目的：评估专用（筛查）设备获得的视网膜灵敏度值是否可用于功能识别早期和中期年龄相关性黄斑变性（ARMD）。
在 5 个研究地点，使用全自动眼底周边仪结合图像稳定扫描激光检眼镜对 200 名 ARMD 患者（319 只眼）进行检测。年龄匹配的对照组由 200 名正常人组成。记录灵敏度点值（S 值）、平均视网膜灵敏度、低于 24dB 的点数（K 值，正常值的截止值）和固视稳定性。
在 319 只眼中，164 只被归类为早期（AREDS 2），155 只为中期（AREDS 3）ARMD。与正常组相比，ARMD 患者的平均视网膜灵敏度显著降低（p < 0.001）。正常人和 ARMD 患者的 K 值不同（p < 0.001）。早期和中期 ARMD 患者的固视稳定性无差异。
与年龄匹配的正常人相比，早期和中期 ARMD 患者的黄斑敏感性降低。这些变化可能可以通过筛查设备检测到。
