Xu Haiyue, Wang Yu, Zou Bo, Liu Meilin, Dai Chunmeng, Ding Xiaoxia
Department of Ophthalmology, Fushun Eye Hospital, Fushun, Liaoning, China.
Transl Vis Sci Technol. 2025 Jul 1;14(7):24. doi: 10.1167/tvst.14.7.24.
The purpose of this study was to investigate changes in visual function following surgery and identify predictors of postoperative visual function in patients with idiopathic epiretinal membrane (iERM).
This retrospective study included 37 eyes with iERM. Macular structure was assessed using optical coherence tomography (OCT) and OCT angiography (OCTA), whereas visual function was evaluated using best-corrected visual acuity (BCVA) and microperimetry. All parameters were measured preoperatively (baseline) and at 3 and 6 months postoperatively. Associations between macular structural parameters and visual function outcomes were analyzed.
Central retinal thickness (CRT) decreased significantly at both 3 and 6 months postoperatively. Parafoveal vessel density (PFVD) of the deep capillary plexus (DCP) and BCVA improved significantly at 3 months, with no significant changes observed between 3 and 6 months. Retinal sensitivity (RS) and fixation stability (FS) demonstrated significant improvement at 6 months, whereas macular integrity (MI) showed no significant postoperative changes. Multiple linear regression analysis revealed that baseline PFVD of the DCP was a significant predictor of postoperative BCVA. Logistic regression analysis identified baseline PFVD of the DCP as an independent predictor of postoperative FS improvement.
BCVA, RS, and FS improve significantly following iERM surgery, with BCVA improving earlier than microperimetry parameters. A higher baseline PFVD of the DCP is a significant prognostic factor for better BCVA and FS improvement.
Microperimetry offers an objective and quantitative evaluation of macular functional changes after iERM surgery. PFVD of the DCP, as measured by OCTA, can serve as a valuable predictor of BCVA and FS outcomes postoperatively.
本研究旨在调查特发性视网膜前膜（iERM）患者手术后视觉功能的变化，并确定术后视觉功能的预测因素。
这项回顾性研究纳入了37只患有iERM的眼睛。使用光学相干断层扫描（OCT）和OCT血管造影（OCTA）评估黄斑结构，而使用最佳矫正视力（BCVA）和微视野检查评估视觉功能。所有参数均在术前（基线）以及术后3个月和6个月进行测量。分析黄斑结构参数与视觉功能结果之间的关联。
术后3个月和6个月时，中心视网膜厚度（CRT）均显著降低。深层毛细血管丛（DCP）的黄斑旁血管密度（PFVD）和BCVA在术后3个月时显著改善，在3个月至6个月之间未观察到显著变化。视网膜敏感度（RS）和注视稳定性（FS）在术后6个月时显示出显著改善，而黄斑完整性（MI）术后无显著变化。多元线性回归分析显示，DCP的基线PFVD是术后BCVA的显著预测因素。逻辑回归分析确定DCP的基线PFVD是术后FS改善的独立预测因素。
iERM手术后BCVA、RS和FS显著改善，BCVA的改善早于微视野检查参数。DCP的基线PFVD较高是BCVA更好和FS改善的重要预后因素。
微视野检查为iERM手术后黄斑功能变化提供了客观定量评估。通过OCTA测量的DCP的PFVD可作为术后BCVA和FS结果的有价值预测指标。
