Laboratório de Neurociências, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC Brazil.
Oxid Med Cell Longev. 2010 Sep-Oct;3(5):325-31. doi: 10.4161/oxim.3.5.13109. Epub 2010 Sep 1.
A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the effects of acute and chronic administration of harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) or saline in lipid and protein oxidation levels and superoxide dismutase (SOD) and catalase (CAT) activities in rat prefrontal cortex and hippocampus. Acute and chronic treatments with imipramine and harmine reduced lipid and protein oxidation, compared to control group in prefrontal cortex and hippocampus. The SOD and CAT activities increased with acute and chronic treatments with imipramine and harmine, compared to control group in prefrontal cortex and hippocampus. In conclusion, our results indicate positive effects of imipramine antidepressant and β-carboline harmine of oxidative stress parameters, increasing SOD and CAT activities and decreasing lipid and protein oxidation.
越来越多的证据表明，活性氧（ROS）可能在抑郁症的病理生理学中发挥重要作用。有证据表明，β-咔啉哈尔明可能是治疗抑郁症的潜在治疗靶点。本研究评估了急性和慢性给予哈尔明（5、10 和 15 mg/kg）和丙咪嗪（10、20 和 30 mg/kg）或生理盐水对大鼠前额叶皮层和海马脂质和蛋白质氧化水平以及超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性的影响。与对照组相比，急性和慢性给予丙咪嗪和哈尔明可降低前额叶皮层和海马中的脂质和蛋白质氧化水平。与对照组相比，急性和慢性给予丙咪嗪和哈尔明可增加前额叶皮层和海马中的 SOD 和 CAT 活性。总之，我们的结果表明丙咪嗪抗抑郁药和β-咔啉哈尔明对氧化应激参数具有积极影响，可增加 SOD 和 CAT 活性并降低脂质和蛋白质氧化。
