Laboratorio de Farmacología Molecular del Centro de Investigación y Desarrollo de Medicamentos, Ave. 26 No. 1605, Nuevo Vedado, Havana, Cuba.
Molecules. 2010 Dec 9;15(12):9035-45. doi: 10.3390/molecules15129035.
It has been accepted that neuroinflammation, oxidative stress and glial activation are involved in the central sensitization underlying neuropathic pain. Vimang is an aqueous extract of Mangifera indica L. traditionally used in Cuba for its analgesic, anti-inflammatory, antioxidant and immunomodulatory properties. Several formulations are available, and also for mangiferin, its major component. Preclinical studies demonstrated that these products prevented tumor necrosis factor α -induced IκB degradation and the binding of nuclear factor κB to DNA, which induces the transcription of genes implicated in the expression of some mediators and enzymes involved in inflammation, pain, oxidative stress and synaptic plasticity. In this paper we propose its potential utility in the neuropathic pain treatment. This hypothesis is supported in the cumulus of preclinical and clinical evidence around the extract and mangiferin, its major component, and speculates about the possible mechanism of action according to recent advances in the physiopathology of neuropathic pain.
已经公认，神经炎症、氧化应激和神经胶质细胞激活与神经病理性疼痛的中枢敏化有关。Vimang 是芒果的水提物，在古巴传统上用于其镇痛、抗炎、抗氧化和免疫调节特性。有几种制剂，也有芒果苷，它是主要成分。临床前研究表明，这些产品可预防肿瘤坏死因子-α诱导的 IκB 降解和核因子 κB 与 DNA 的结合，从而诱导涉及一些介质和酶表达的基因转录，这些介质和酶参与炎症、疼痛、氧化应激和突触可塑性。本文提出了其在治疗神经病理性疼痛中的潜在应用。这一假说得到了围绕提取物和芒果苷的临床前和临床证据的支持，其主要成分，并根据神经病理性疼痛生理病理学的最新进展推测了可能的作用机制。
