Weisman Yosef
Faculty of Medicine, Tel Aviv University, and Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel.
Pediatr Endocrinol Rev. 2010 Dec;8(2):103-7.
In the past three decades, our understanding of the physiologic functions of vitamin D1 has extended and includes many unexpected non-classic biological actions. Vitamin D receptors (VDR) and 25-hydroxyvitamin D-1αhydroxylase, the enzyme responsible for the production of 1,25(OH)2D3, the active form of vitamin D, are present in many tissues which are not associated with calcium or bone metabolism. Indeed, 1,25(OH)2D regulates cell proliferation, differentiation and apoptosis in many normal and cancer cells. Epidemiologic studies have shown that vitamin D deficiency increases the risk of cancer, cardiovascular disease and autoimmune disease. However, large scale randomized controlled intervention trials are needed to prove the effects of vitamin D on the prevention and treatment of these diseases. Expression of vitamin D or its metabolites without a subscript refer to both vitamin D2 and vitamin D3 or their metabolites.
在过去三十年中，我们对维生素D1生理功能的理解得到了扩展，其生理功能包括许多意想不到的非经典生物学作用。维生素D受体（VDR）和25-羟基维生素D-1α羟化酶（负责生成维生素D的活性形式1,25(OH)2D3的酶）存在于许多与钙或骨代谢无关的组织中。事实上，1,25(OH)2D在许多正常细胞和癌细胞中调节细胞增殖、分化和凋亡。流行病学研究表明，维生素D缺乏会增加患癌症、心血管疾病和自身免疫性疾病的风险。然而，需要大规模随机对照干预试验来证明维生素D对这些疾病预防和治疗的效果。未加下标表示的维生素D或其代谢物是指维生素D2和维生素D3或它们的代谢物。
