Center for Comparative Medicine, University of California, Davis, California 95616, USA.
Nat Rev Immunol. 2011 Jan;11(1):34-46. doi: 10.1038/nri2901. Epub 2010 Dec 10.
During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.
在发育过程中，具有自身反应性抗原受体的 B 和 T 细胞通常从 repertoire 中删除，以避免自身免疫性疾病。矛盾的是，小鼠中的先天样 B-1 细胞被正向选择为自身反应性，并形成了一个长寿、自我更新的 B 细胞池，这些细胞产生了大部分循环自然 IgM 抗体。这篇综述概述了塑造小鼠 B-1 细胞库的发育过程，概述了 B-1 细胞在稳态和宿主防御期间的功能，并讨论了人类中可能存在的功能性 B-1 细胞同源物。
