Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306-4340, USA.
Int J Obes (Lond). 2010 Dec;34 Suppl 2:S53-8. doi: 10.1038/ijo.2010.240.
It is standard practice in preclinical biomedical research to house mammalian model organisms at an ambient temperature substantially below the thermoneutral zone. These experimental studies are performed using animals that are chronically challenged by mild cold stress. This condition increases food intake, metabolic rate, sympathetic activity, blood pressure and heart rate. Furthermore, this condition alters the behavioral and physiological responses to drug administration, energy restriction and overfeeding. This paper will review these observations, which must be understood in the context of phenotyping small mammals to enhance our understanding of the biology of human disease.
在基础生物医学研究中，标准做法是将哺乳动物模型生物饲养在环境温度远低于其热中性区的环境中。这些实验研究使用的动物长期受到轻度冷应激的挑战。这种情况会增加食物摄入、代谢率、交感神经活动、血压和心率。此外，这种情况还会改变对药物给药、能量限制和过度喂养的行为和生理反应。本文将综述这些观察结果，这些结果必须在对小型哺乳动物进行表型分析的背景下加以理解，以增强我们对人类疾病生物学的认识。
