Watanabe Ryou, Nakazawa Toru, Fuse Nobuo
Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Clin Ophthalmol. 2010 Oct 27;4:1243-7. doi: 10.2147/OPTH.S14550.
The histopathology of posterior corneal vesicles (PCV) has not yet been revealed. A 15-year-old girl, who was diagnosed by slit-lamp microscopy as PCV, was examined using specular microscopy, in vivo confocal microscopy, and anterior segment OCT (optical coherence tomography). Anterior segment OCT showed that the thickness of both corneas was within normal limits. At the same time, in vivo confocal microscopy revealed endothelial cells in the rounded dark areas, acellular hyporeflective layers on the Descemet's membrane, and hyperreflective linear lesions. These findings were not reported previously by slit-lamp and specular microscopy. The abnormal findings only existed at the Descemet's membrane and corneal endothelial layer. Previous reports dealing with posterior polymorphous dystrophy (PPMD) examined using in vivo confocal microscopy reported almost the same findings, suggesting that PCV and PPMD may be the same at the microstructural level.
后弹力层角膜小泡（PCV）的组织病理学尚未明确。一名15岁女孩，经裂隙灯显微镜检查诊断为PCV，采用镜面显微镜、活体共聚焦显微镜和眼前节光学相干断层扫描（OCT）进行检查。眼前节OCT显示双眼角膜厚度在正常范围内。同时，活体共聚焦显微镜显示圆形暗区内有内皮细胞、后弹力层上有无细胞低反射层以及高反射线性病变。这些发现此前裂隙灯和镜面显微镜均未报道。异常表现仅存在于后弹力层和角膜内皮层。先前关于使用活体共聚焦显微镜检查的后极性多形性营养不良（PPMD）的报告显示了几乎相同的发现，提示PCV和PPMD在微观结构水平上可能相同。
