Xu Xiangdong, Broome Elizabeth H, Rashidi Hooman H, South Sarah T, Dell'aquila Marie L, Wang Huan-You
Division of Clinical Pathology, Department of Pathology, University of California San Diego Health Sciences, 3855 Health Science Drive, La Jolla, California 92093, USA.
Int J Clin Exp Pathol. 2010 Sep 12;3(8):798-807.
We report a CD20dim- positive T-cell large granular lymphocytic (T-LGL) leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. This patient was first diagnosed with T-LGL leukemia with dim CD20 expression, which by itself was a rare entity. He received no treatment for T-LGL leukemia. The patient later developed a hairy cell leukemia, which went into complete clinical remission after one cycle of 2-CdA. Five years later, he was diagnosed with a third malignancy, plasma cell myeloma. Complex cytogenetic aberrancies were present at the time when plasma cell myeloma was diagnosed. This is the first report, to the best of our knowledge, in the English literature with the aforementioned three distinct hematopoietic malignancies in one patient.
我们报告了一例同时患有毛细胞白血病和浆细胞骨髓瘤的患者发生的CD20弱阳性阳性T细胞大颗粒淋巴细胞（T-LGL）白血病。该患者最初被诊断为CD20表达弱阳性的T-LGL白血病，其本身就是一种罕见的疾病。他未接受T-LGL白血病的治疗。该患者后来发展为毛细胞白血病，在接受一个周期的2-氯脱氧腺苷治疗后达到完全临床缓解。五年后，他被诊断出患有第三种恶性肿瘤——浆细胞骨髓瘤。在诊断浆细胞骨髓瘤时存在复杂的细胞遗传学异常。据我们所知，这是英文文献中首例关于一名患者同时患有上述三种不同造血系统恶性肿瘤的报告。
