Zhang Yaxia, Taheri Zohreh M, Jorda Merce
Department of Pathology, University of Miami-Miller School of Medicine/Jackson Memorial Hospital, Miami, FL 33136, USA.
Patholog Res Int. 2010 Jan 4;2010:846571. doi: 10.4061/2010/846571.
Systemic lymph node metastasis is a rare event in malignant mesothelioma. It is even more exceptional when systemic lymph node metastasis is the initial clinical presentation. Review of literature discloses only four cases in which metastatic lymphadenopathy was the only symptom of malignant mesothelioma. We, herewith, report three cases where the initial diagnosis of malignant mesothelioma was made by biopsy of enlarged lymph nodes, which were the only clinical presentation. Immunohistochemistry played a pivotal role in elucidating the mesothelial origin of their unusual systemic lymph node metastasis.
系统性淋巴结转移在恶性间皮瘤中是一种罕见事件。当系统性淋巴结转移作为初始临床表现时则更为罕见。文献回顾仅发现4例转移性淋巴结病是恶性间皮瘤的唯一症状。在此，我们报告3例通过肿大淋巴结活检确诊为恶性间皮瘤的病例，肿大淋巴结是唯一的临床表现。免疫组化在阐明其不寻常的系统性淋巴结转移的间皮来源方面发挥了关键作用。
