Department of Pathology, Mahatma Gandhi Medical College and Research Institute, Puducherry-607402, India.
Clin Med Insights Oncol. 2010 Nov 21;4:127-31. doi: 10.4137/CMO.S6163.
We present a case of basal cell adenocarcinoma (BCAC) in the tongue in a 65-year old male. This is an extremely rare presentation. BCAC generally occurs in the parotid gland and rarely involves the minor salivary glands. Few cases have been reported in literature with a variable presentation. The biopsy was formalin-fixed and paraffin-embedded. The sections were stained with routine Hematoxylin and Eosin. Immunohistochemistry was performed. Hematoxylin and eosin staining showed tumour composed of variable sized and shaped, nests and sheets of basaloid epithelial cells having hyperchromatic to vesicular nuclei. Immunohistochemistry was positive for Pancytokeratin, Epithelial membrane antigen and p53. The clinicopathological features and the cellular immunophenotype addressed the diagnosis towards BCAC of the tongue. The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment.
我们报告了一例发生在 65 岁男性舌部的基底细胞腺癌（BCAC）。这是一种极其罕见的表现。BCAC 通常发生在腮腺，很少累及小唾液腺。文献中报道的少数病例表现各异。活检标本经福尔马林固定和石蜡包埋。切片用常规苏木精和伊红染色。进行了免疫组织化学染色。苏木精和伊红染色显示肿瘤由大小和形状不同的巢状和片状基底样上皮细胞组成，细胞核深染至泡状。免疫组织化学染色显示细胞角蛋白、上皮膜抗原和 p53 阳性。临床病理特征和细胞免疫表型提示诊断为舌部 BCAC。本报告的目的是提高对这种罕见疾病的认识，并复习和讨论鉴别诊断和治疗中的重要注意事项。
