Altraif Ibrahim, Handoo Fayaz A, Alsaad Khaled O, Gublan Adel
Department of Hepatobiliary and Liver Transplantation, King Abdulaziz Medical City, P.O. Box 22490, Riyadh 11426, Saudi Arabia.
Patholog Res Int. 2010 May 16;2010:648089. doi: 10.4061/2010/648089.
Although systemic amyloidosis of amyloid-associated protein (AA) type (secondary or reactive amyloidosis) frequently involves the liver, it rarely causes clinically apparent liver disease. Mild elevation of alkaline phosphatase and hepatomegaly are the most common biochemical and clinical findings, respectively. We report a case of systemic amyloidosis of AA type, which clinically presented as subacute hepatic failure and resulted in a fatal clinical course in a 69-year-old man. To the best of our knowledge, this is the fifth case of hepatic amyloidosis of AA type that clinically presented as fatal subacute hepatic failure, an unusual clinical presentation for hepatic involvement by systemic AA-type amyloid.
尽管淀粉样蛋白A（AA）型系统性淀粉样变性（继发性或反应性淀粉样变性）常累及肝脏，但很少引起临床上明显的肝脏疾病。碱性磷酸酶轻度升高和肝肿大分别是最常见的生化和临床发现。我们报告一例AA型系统性淀粉样变性病例，该病例临床上表现为亚急性肝衰竭，导致一名69岁男性出现致命的临床病程。据我们所知，这是临床上表现为致命性亚急性肝衰竭的第五例AA型肝淀粉样变性病例，这是系统性AA型淀粉样变性累及肝脏的一种不寻常的临床表现。
