Köklü S, Odemiş B, Cengiz C, Yüksel O, Usküdar O, Turhan N
Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey.
Dig Liver Dis. 2006 Mar;38(3):208-10. doi: 10.1016/j.dld.2005.05.014. Epub 2006 Feb 7.
Systemic amyloidosis frequently involves liver, however, clinically apparent liver disease is rare and, if observed, is usually mild. Rarely, primary amyloidosis may present with evidence of portal hypertension or hepatic failure. Although secondary amyloidosis may involve the liver and rarely causes liver pathologies such as cholestatic hepatitis and portal hypertension, to our knowledge, hepatic failure due to secondary amyloidosis has been reported once before. Herein, we presented a woman with subacute fulminant hepatic failure who had no known history of a chronic disease other than episodes of urinary tract infection, and secondary amyloidosis was diagnosed with post-mortem liver biopsy.
系统性淀粉样变性常累及肝脏，然而，临床上明显的肝脏疾病罕见，即便观察到，通常也较轻微。原发性淀粉样变性极少表现出门静脉高压或肝衰竭的迹象。虽然继发性淀粉样变性可能累及肝脏，且很少引发诸如胆汁淤积性肝炎和门静脉高压等肝脏病变，但据我们所知，继发性淀粉样变性导致肝衰竭此前仅有过一次报道。在此，我们报告了一名患有亚急性暴发性肝衰竭的女性，除尿路感染发作外无其他已知慢性病史，尸检肝脏活检诊断为继发性淀粉样变性。
