蛋白激酶C定位的高特异性调节剂：在心力衰竭中的应用
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.
作者信息
Qvit Nir, Mochly-Rosen Daria
机构信息
Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford CA 94305-5174.
出版信息
Drug Discov Today Dis Mech. 2010 Summer;7(2):e87-e93. doi: 10.1016/j.ddmec.2010.07.001.
Abstract
Heart failure (HF) in which the blood supply does not match the body's needs, affects 10% of the population over 65 years old. The protein kinase C (PKC) family of kinases has a key role in normal and disease states. Here we discuss the role of PKC in HF and focus on the use of specific PKC regulators to identify the mechanism leading to this Pathology and potential leads for therapeutics.
摘要
心力衰竭（HF）是指血液供应无法满足身体需求的一种病症，影响着10%的65岁以上人群。蛋白激酶C（PKC）激酶家族在正常和疾病状态中都起着关键作用。在此，我们将探讨PKC在HF中的作用，并着重关注使用特定的PKC调节剂来确定导致这种病理状况的机制以及潜在的治疗线索。
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