Penn Israel, Halgrimson Charles G, Starzl Thomas E
Department of Surgery, University of Colorado School of Medicine and the Denver Veterans Administration Hospital, Denver, Colo.
Ann N Y Acad Sci. 1970 Jul;170:251-258. doi: 10.1111/j.1749-6632.1970.tb37018.x.
Until quite recently it was possible to give only highly tentative opinions on the role of liver transplantation in the treatment of patients dying of incurable liver disease. Now, a much more authoritative position concerning clinical liver transplantation can be taken, since there have been six patients who have lived for more than a year after removal of their own diseased livers and replacement with cadaveric organs.The mortality has been high, just as it was in the first trials with renal transplantation. Nevertheless, we believe that the future role of liver transplantation in hepatic disease will not be fundamentally different than cadaveric kidney transplantation in the field of renal disease. In this paper we will give the justification for this optimistic view, mention the indications for such operations as they have become clear in the last year and, above all, focus attention upon the errors in technique or judgment we have made which have accounted for most of the early deaths in our experience.
直到最近，对于肝移植在治疗患有不治之症肝病患者中的作用，还只能给出非常初步的意见。现在，关于临床肝移植可以有一个更具权威性的观点，因为已有6名患者在切除自身患病肝脏并用尸体器官替代后存活了一年多。死亡率一直很高，就像肾移植的首次试验那样。然而，我们相信肝移植在肝病治疗中的未来作用与尸体肾移植在肾病领域中的作用在本质上不会有太大不同。在本文中，我们将阐述这种乐观看法的依据，提及过去一年中已明确的此类手术的适应症，最重要的是，关注我们在技术或判断上所犯的错误，在我们的经验中，这些错误导致了大多数早期死亡病例。
