心脏调节系统在短时间尺度上的内在动力学：从实验到建模
Intrinsic dynamics of heart regulatory systems on short time-scales: from experiment to modelling.
作者信息
Khovanov I A, Khovanova N A, McClintock P V E, Stefanovska A
机构信息
Department of Physics, Lancaster University, Lancaster LA1 4YB, UK.
出版信息
J Stat Mech. 2009 Jan;2009. doi: 10.1088/1742-5468/2009/01/P01016.
We discuss open problems related to the stochastic modeling of cardiac function. The work is based on an experimental investigation of the dynamics of heart rate variability (HRV) in the absence of respiratory perturbations. We consider first the cardiac control system on short time scales via an analysis of HRV within the framework of a random walk approach. Our experiments show that HRV on timescales of less than a minute takes the form of free diffusion, close to Brownian motion, which can be described as a non-stationary process with stationary increments. Secondly, we consider the inverse problem of modeling the state of the control system so as to reproduce the experimentally observed HRV statistics of. We discuss some simple toy models and identify open problems for the modelling of heart dynamics.
我们讨论了与心脏功能随机建模相关的开放性问题。这项工作基于在无呼吸干扰情况下对心率变异性（HRV）动态的实验研究。我们首先通过在随机游走方法的框架内分析HRV来研究短时间尺度上的心脏控制系统。我们的实验表明，小于一分钟时间尺度上的HRV呈现自由扩散的形式，接近布朗运动，可描述为具有平稳增量的非平稳过程。其次，我们考虑对控制系统状态进行建模的逆问题，以便重现实验观察到的HRV统计数据。我们讨论了一些简单的玩具模型，并确定了心脏动力学建模的开放性问题。
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