Popel Aleksander S, Johnson Paul C
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205;
Annu Rev Fluid Mech. 2005 Jan 1;37:43-69. doi: 10.1146/annurev.fluid.37.042604.133933.
Major experimental and theoretical studies on microcirculation and hemorheology are reviewed with the focus on mechanics of blood flow and the vascular wall. Flow of the blood formed elements (red blood cells (RBCs), white blood cells or leukocytes (WBCs) and platelets) in individual arterioles, capillaries and venules, and in microvascular networks is discussed. Mechanical and rheological properties of the formed elements and their interactions with the vascular wall are reviewed. Short-term and long-term regulation of the microvasculature is discussed; the modes of regulation include metabolic, myogenic and shear-stress-dependent mechanisms as well as vascular adaptation such as angiogenesis and vascular remodeling.
本文综述了关于微循环和血液流变学的主要实验和理论研究，重点关注血流动力学和血管壁力学。讨论了血液有形成分（红细胞、白细胞和血小板）在单个小动脉、毛细血管和小静脉以及微血管网络中的流动情况。综述了有形成分的力学和流变学特性及其与血管壁的相互作用。探讨了微血管的短期和长期调节；调节方式包括代谢、肌源性和剪切应力依赖性机制，以及血管适应，如血管生成和血管重塑。
