临床异种移植
Clinical xenotransplantation.
作者信息
Starzl Thomas E, Murase Noriko, Tzakis Andreas, Fung John J, Todo Satoru, Demetris Anthony J, Manez Rafael, Marino Ignazio R, Valdivia Luis
机构信息
Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, U.S.A.
出版信息
Xenotransplantation. 1994 Aug;1(1):3-7. doi: 10.1111/j.1399-3089.1994.tb00044.x.
Abstract
Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies. However, there was evidence of complement activation in both cases, which in retrospect was thought to explain the unsatisfactory outcome. Strategies to deal with this problem are discussed.
摘要
两只狒狒肝脏异种移植到B型病毒性肝炎患者体内，维持生命70天和26天，但尽管在系列活检中未发现明显体液或细胞排斥的最小组织病理学表现或无此表现，其功能仍未达到最佳状态。然而，两例均有补体激活的证据，事后认为这可以解释不尽人意的结果。文中讨论了处理该问题的策略。
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本文引用的文献
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RENAL HETEROTRANSPLANTATION FROM BABOON TO MAN: EXPERIENCE WITH 6 CASES.从狒狒到人类的肾异种移植：6例经验
Transplantation. 1964 Nov;2:752-76. doi: 10.1097/00007890-196411000-00009.
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RENAL HOMOGRAFTS IN PATIENTS WITH MAJOR DONOR-RECIPIENT BLOOD GROUP INCOMPATIBILITIES.主要供受者血型不相容患者的肾移植
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Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance.全器官移植后的细胞迁移与嵌合现象：移植物接受的基础
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4
Prolonging discordant xenograft survival with anticomplement reagents K76COOH and FUT175.使用抗补体试剂K76COOH和FUT175延长异种移植不和谐存活期。
Transplantation. 1993 Apr;55(4):709-13. doi: 10.1097/00007890-199304000-00004.
5
Humoral rejection associated with antidonor lymphocytotoxic antibodies following liver transplantation.肝移植后与抗供体淋巴细胞毒性抗体相关的体液排斥反应。
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6
Donor species complement after liver xenotransplantation. The mechanism of protection from hyperacute rejection.肝异种移植后的供体物种补体。免受超急性排斥反应的保护机制。
Transplantation. 1994 Mar 27;57(6):918-22. doi: 10.1097/00007890-199403270-00025.
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Baboon-to-human liver transplantation.狒狒到人类的肝脏移植。
Lancet. 1993 Jan 9;341(8837):65-71. doi: 10.1016/0140-6736(93)92553-6.
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Prospects of clinical xenotransplantation.临床异种移植的前景。
Transplant Proc. 1994 Jun;26(3):1082-8.
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Regeneration-induced accelerated rejection in reduced-size liver grafts.
Transplantation. 1994 Feb;57(3):336-40. doi: 10.1097/00007890-199402150-00004.
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N Engl J Med. 1968 Mar 21;278(12):642-8. doi: 10.1056/NEJM196803212781202.
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