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妊娠与哮喘和过敏性疾病:综述

Asthma and allergic diseases in pregnancy a review.

机构信息

Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Austria.

出版信息

World Allergy Organ J. 2009 Mar;2(3):26-36. doi: 10.1186/1939-4551-2-3-26.

Abstract

Asthma and allergic disorders can affect the course and outcome of pregnancy. Pregnancy itself may also affect the course of asthma and related diseases. Optimal management of these disorders during pregnancy is vital to ensure the welfare of the mother and the baby.Specific pharmacological agents for treatment of asthma or allergic diseases must be cautiously selected and are discussed here with respect to safety considerations in pregnancy. Although most drugs do not harm the fetus, this knowledge is incomplete. Any drug may carry a small risk that must be balanced against the benefits of keeping the mother and baby healthy. The goals and principles of management for acute and chronic asthma, rhinitis, and dermatologic disorders are the same during pregnancy as those for asthma in the general population.Diagnosis of allergy during pregnancy should mainly consist of the patient's history and in vitro testing.The assured and well-evaluated risk factors revealed for sensitization in mother and child are very limited, to date, and include alcohol consumption, exposure to tobacco smoke, maternal diet and diet of the newborn, drug usage, and insufficient exposure to environmental bacteria. Consequently, the recommendations for primary and secondary preventive measures are also very limited in number and verification.

摘要

哮喘和过敏疾病会影响妊娠的过程和结局。妊娠本身也可能影响哮喘和相关疾病的病程。在妊娠期间对这些疾病进行最佳管理对于确保母婴健康至关重要。本文讨论了妊娠期间治疗哮喘或过敏疾病的特定药物,这些药物的选择需要谨慎,应考虑其安全性。虽然大多数药物不会损害胎儿,但目前这方面的知识还不完全。任何药物都可能存在一定的风险,必须权衡利弊,以确保母亲和婴儿的健康。在妊娠期间,急性和慢性哮喘、鼻炎和皮肤病的管理目标和原则与普通人群中的哮喘相同。妊娠期间的过敏诊断主要应依据患者的病史和体外检测。迄今为止,明确且经过良好评估的母婴致敏的危险因素非常有限,包括饮酒、接触烟草烟雾、母亲的饮食和新生儿的饮食、药物使用以及环境细菌暴露不足。因此,初级和二级预防措施的建议数量和验证也非常有限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecac/3650999/d6f97a9c5b2b/1939-4551-2-3-26-1.jpg

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