Lund Jared J, Stratman Erik J, Jose Deepa, Xia Ling, Wilson Deborah, Moizuddin Mohammed
Department of Dermatology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, 54449, USA.
Autoimmune Dis. 2010 Aug 24;2011:176749. doi: 10.4061/2010/176749.
Sweet syndrome (SS) (Acute Febrile Neutrophilic Dermatosis) has been reported in association with autoimmune phenomena including relapsing polychondritis, drug-induced lupus, and the development of antineutrophil cytoplasmic antibodies (ANCAs). However, a combination of these autoimmune features has not been reported. Herein, we report a case of drug-induced bullous SS with ocular and mucosal involvement, glomerulonephritis, and multiple autoimmune features including clinical polychondritis with antitype II collagen antibodies, ANCAs, antinuclear (HEp-2), and antihistone antibodies in a patient on hydralazine and carbamazepine.
Sweet综合征(SS)(急性发热性嗜中性皮病)已被报道与自身免疫现象相关,包括复发性多软骨炎、药物性狼疮以及抗中性粒细胞胞浆抗体(ANCA)的产生。然而,这些自身免疫特征的组合尚未见报道。在此,我们报告一例药物性大疱性SS患者,该患者有眼部和黏膜受累、肾小球肾炎以及多种自身免疫特征,包括伴有抗II型胶原抗体、ANCA、抗核(HEp-2)和抗组蛋白抗体的临床多软骨炎,患者正在服用肼屈嗪和卡马西平。