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具有多种自身免疫特征的药物性大疱性Sweet综合征

Drug-induced bullous sweet syndrome with multiple autoimmune features.

作者信息

Lund Jared J, Stratman Erik J, Jose Deepa, Xia Ling, Wilson Deborah, Moizuddin Mohammed

机构信息

Department of Dermatology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, 54449, USA.

出版信息

Autoimmune Dis. 2010 Aug 24;2011:176749. doi: 10.4061/2010/176749.

DOI:10.4061/2010/176749
PMID:21152216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2989706/
Abstract

Sweet syndrome (SS) (Acute Febrile Neutrophilic Dermatosis) has been reported in association with autoimmune phenomena including relapsing polychondritis, drug-induced lupus, and the development of antineutrophil cytoplasmic antibodies (ANCAs). However, a combination of these autoimmune features has not been reported. Herein, we report a case of drug-induced bullous SS with ocular and mucosal involvement, glomerulonephritis, and multiple autoimmune features including clinical polychondritis with antitype II collagen antibodies, ANCAs, antinuclear (HEp-2), and antihistone antibodies in a patient on hydralazine and carbamazepine.

摘要

Sweet综合征(SS)(急性发热性嗜中性皮病)已被报道与自身免疫现象相关,包括复发性多软骨炎、药物性狼疮以及抗中性粒细胞胞浆抗体(ANCA)的产生。然而,这些自身免疫特征的组合尚未见报道。在此,我们报告一例药物性大疱性SS患者,该患者有眼部和黏膜受累、肾小球肾炎以及多种自身免疫特征,包括伴有抗II型胶原抗体、ANCA、抗核(HEp-2)和抗组蛋白抗体的临床多软骨炎,患者正在服用肼屈嗪和卡马西平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be5/2989706/744624186f92/AD2010-176749.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be5/2989706/22eec4ff920a/AD2010-176749.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be5/2989706/3d2c85cfe59f/AD2010-176749.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be5/2989706/744624186f92/AD2010-176749.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be5/2989706/22eec4ff920a/AD2010-176749.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be5/2989706/3d2c85cfe59f/AD2010-176749.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be5/2989706/744624186f92/AD2010-176749.003.jpg

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本文引用的文献

1
[Sweet's syndrome as the presenting manifestation of relapsing polychondritis].[Sweet综合征作为复发性多软骨炎的首发表现]
Rev Med Interne. 2010 May;31(5):e1-3. doi: 10.1016/j.revmed.2009.05.013. Epub 2010 Apr 22.
2
Do antineutrophil cytoplasmic antibodies (ANCA) play a key role in neutrophilic dermatoses? A case of propylthiouracil-induced neutrophilic dermatosis with positive perinuclear ANCA.抗中性粒细胞胞质抗体 (ANCA) 在中性粒细胞皮肤病中起关键作用吗?一例丙基硫氧嘧啶诱导的伴有核周型 ANCA 阳性的中性粒细胞皮肤病。
Clin Exp Dermatol. 2010 Jun;35(4):406-8. doi: 10.1111/j.1365-2230.2009.03612.x. Epub 2009 Oct 23.
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一名老年起病的原发性干燥综合征患者接受羟氯喹治疗后出现Sweet综合征
Medicines (Basel). 2019 Nov 15;6(4):111. doi: 10.3390/medicines6040111.
4
Neutrophilic Dermatoses in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A French Multicenter Study of 17 Cases and Literature Review.抗中性粒细胞胞浆抗体相关血管炎中的嗜中性皮肤病:一项法国多中心17例病例研究及文献综述
Medicine (Baltimore). 2016 Mar;95(11):e2957. doi: 10.1097/MD.0000000000002957.
5
Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report.肼屈嗪诱发的抗中性粒细胞胞浆抗体阳性肾血管炎,表现为血管炎综合征、急性肾炎及令人费解的皮疹:一例报告
J Med Case Rep. 2013 Jan 14;7:20. doi: 10.1186/1752-1947-7-20.
Sweet syndrome subsequent to relapsing polychondritis and myelodysplastic syndrome in a Japanese patient.
一名日本患者在复发性多软骨炎和骨髓增生异常综合征后出现Sweet综合征。
Acta Derm Venereol. 2008;88(5):517-9. doi: 10.2340/00015555-0488.
4
Concomitant Sweet's syndrome and relapsing polychondritis.伴发Sweet综合征和复发性多软骨炎。
Acta Derm Venereol. 2007;87(5):426-7. doi: 10.2340/00015555-0263.
5
Sweet's syndrome: a spectrum of unusual clinical presentations and associations.斯威特综合征:一系列不寻常的临床表现及关联。
Br J Dermatol. 2007 Mar;156(3):480-5. doi: 10.1111/j.1365-2133.2006.07677.x.
6
Drug-induced systemic lupus erythematosus after 7 years of treatment with carbamazepine.卡马西平治疗7年后发生药物性系统性红斑狼疮。
Acta Biomed. 2006 Apr;77(1):17-9.
7
Bullous variant of Sweet's syndrome.斯威特综合征的大疱性变体。
Int J Dermatol. 2005 Nov;44(11):946-7. doi: 10.1111/j.1365-4632.2004.02287.x.
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Bullous Sweet's syndrome in congenital neutropenia: association with pegfilgrastim.先天性中性粒细胞减少症中的大疱性斯威特综合征:与培非格司亭的关联。
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Int J Dermatol. 2004 Oct;43(10):772-7. doi: 10.1111/j.1365-4632.2004.02197.x.
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Sweet's syndrome revealing relapsing polychondritis.提示复发性多软骨炎的斯威特综合征。
Int J Dermatol. 2004 Oct;43(10):720-2. doi: 10.1111/j.1365-4632.2004.02198.x.