二棕榈酰磷脂酰胆碱（L-α-卵磷脂）刺激人羊膜中的磷脂酶A2活性。
Dipalmitoylphosphatidylcholine (L-alpha-lecithin) stimulates phospholipase A2 activity in human amnion.
作者信息
Ohtsuka T, Lee H C, Mibe M, Nabekura H, Yamaguchi M, Mori N
机构信息
Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.
出版信息
Biochem Biophys Res Commun. 1990 Jul 16;170(1):328-35. doi: 10.1016/0006-291x(90)91278-z.
In order to investigate the mechanism of dipalmitoylphosphatidylcholine (DPPC, L-alpha-lecithin) stimulation of the prostaglandin E (PGE) production of the amniotic membrane, effects of DPPC (50-800 micrograms/ml) on phospholipase A2 (PLA2), phospholipase C (PLC), PG endoperoxide synthase, and PGE synthase activities of human amniotic membrane were studied. Only PLA2 activity was increased by DPPC, suggesting that lecithin, the major surfactant component, increases the PGE production of the amniotic membrane by activating PLA2.
为了研究二棕榈酰磷脂酰胆碱（DPPC，L-α-卵磷脂）刺激羊膜产生前列腺素E（PGE）的机制，研究了DPPC（50-800微克/毫升）对人羊膜磷脂酶A2（PLA2）、磷脂酶C（PLC）、PG内过氧化物合酶和PGE合酶活性的影响。只有PLA2活性被DPPC增加，这表明主要表面活性剂成分卵磷脂通过激活PLA2增加羊膜的PGE产生。
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