El Fakhri Georges, Ouyang Jinsong
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
Methods Mol Biol. 2011;680:237-46. doi: 10.1007/978-1-60761-901-7_16.
Parkinsonism is a neurological syndrome characterized by tremor, bradykinesia, rigidity, and postural instability. The underlying causes of parkinsonism are numerous. It is of paramount importance to make clean distinction among these diseases. However, the differential diagnosis of parkinsonism is challenging. Simultaneous dual-radionuclide brain SPECT allows us to assess both blood perfusion and dopamine transporter function under the identical physiological conditions. This approach has been proven to improve the differential diagnosis of parkinsonism. The simultaneous (99m)Tc-ECD/(123)I-FP-CIT brain SPECT protocols, which are used for the differential diagnosis of idiopathic Parkinson's disease and multiple system atrophy as well as corticobasal degeneration and progressive supranuclear palsy, are presented.
帕金森综合征是一种以震颤、运动迟缓、肌强直和姿势不稳为特征的神经综合征。帕金森综合征的潜在病因众多。明确区分这些疾病至关重要。然而，帕金森综合征的鉴别诊断具有挑战性。同时进行双放射性核素脑单光子发射计算机断层扫描（SPECT）使我们能够在相同生理条件下评估脑血流灌注和多巴胺转运体功能。这种方法已被证明可改善帕金森综合征的鉴别诊断。本文介绍了用于特发性帕金森病、多系统萎缩以及皮质基底节变性和进行性核上性麻痹鉴别诊断的同时进行的（99m）锝-双半胱乙酯/（123）碘-氟代苯丙胺脑SPECT方案。
