Schütte K, Weigt J, Meyer F, Malfertheiner P
Universitätsklinikum Magdeburg, Klinik für Gastroenterologie, Hepatologie und Infektiologie, Magdeburg, Deutschland.
Zentralbl Chir. 2010 Dec;135(6):528-34. doi: 10.1055/s-0030-1262702. Epub 2010 Dec 13.
In the management of gastrointestinal tumour lesions, palliative treatment has attained an increasing role. As also in curative treatment, an interdisciplinary cooperation between gastroenterologists and surgeons has to be aimed for.
The aim of this study is to illustrate the diagnostic and therapeutic management of frequently occurring diseases in palliative medicine from a gastroenterological point of view.
Complementary short overviews on clinical experience and selectively searched references from the current scientific literature were evaluated.
The symptomatic complex is very heterogeneous and requires an adequate approach taking into account the differential diagnosis. The palliative gastroenterological approach is characterised by the competent care on ascites, management of "malignant intestinal obstruction and obstipation" (MIO) as well as appropriate nutrition and analgetic therapy. The surgical approach is indicated after sequential exhaustion of medical, interventional endoscopic and (eventually) image-guided radiological measures; it comprises creation of a peritoneovenous shunt (ascites), bypass procedures (gastroenteral, biliodigestive, enteroenteral) as well as, in extraordinary cases, resection in addition to the implantation of an i. v. port-a-cath or surgical revision of a PEG / stent complication; in particular, in case of recurrent and massive haemorrhage and perforation (absolute indication), surgery becomes necessary.
A lack of appropriate studies, absence of adequate study results including the difficult initiation of medical studies with palliative intention aggravate a competent evidence-based approach. Therefore, the management is considerably affected by clinical experience.
Efficacious care in palliative visceral medicine requires relevant clinical expertise and interdisciplinary action because of the occurrence of clinical cases in gastroenterology at the border to surgery.
在胃肠道肿瘤病变的管理中,姑息治疗发挥着越来越重要的作用。与根治性治疗一样,也必须致力于胃肠病学家和外科医生之间的跨学科合作。
本研究旨在从胃肠病学角度阐述姑息医学中常见疾病的诊断和治疗管理。
对临床经验的补充性简短综述以及从当前科学文献中选择性检索的参考文献进行了评估。
症状复合体非常异质,需要考虑鉴别诊断采取适当的方法。姑息性胃肠病学方法的特点是对腹水进行有效护理、管理“恶性肠梗阻和便秘”(MIO)以及适当的营养和镇痛治疗。在依次用尽药物、介入内镜和(最终)影像引导下的放射学措施后,才考虑手术方法;它包括创建腹膜静脉分流术(腹水)、旁路手术(胃肠、胆肠、肠肠),以及在特殊情况下,除了植入静脉输液港或手术修复PEG/支架并发症外进行切除;特别是在复发性大量出血和穿孔的情况下(绝对指征),手术是必要的。
缺乏适当的研究、缺乏足够的研究结果,包括难以启动具有姑息意图的医学研究,加剧了基于证据的有效方法的难度。因此,管理很大程度上受到临床经验的影响。
由于胃肠病学中存在与外科交界的临床病例,姑息性内脏医学中的有效护理需要相关的临床专业知识和跨学科行动。