Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
Macromol Biosci. 2011 Feb 11;11(2):296-307. doi: 10.1002/mabi.201000332. Epub 2010 Dec 8.
Cationic micellar nanoparticles self-assembled from a biodegradable amphiphilic copolymer have been used to deliver human TRAIL and paclitaxel simultaneously. Polyplexes formed between paclitaxel-loaded nanoparticles and TRAIL are stable with a size of ≈180 nm and a zeta potential at ≈75 mV. Anticancer effects and apoptotic pathway mechanisms of this drug-and-protein co-delivery system are investigated in various human breast cancer cell lines with different TRAIL sensitivity. The co-delivery nanoparticulate system induces synergistic anti-cancer activities with limited toxicity in non-cancerous cells. An advantage of this co-delivery is a significantly higher anti-cancer effect as compared to free drug and protein formulations.
由可生物降解的两亲性共聚物自组装而成的阳离子胶束纳米颗粒已被用于同时递送 TRAIL 和紫杉醇。负载紫杉醇的纳米颗粒与 TRAIL 之间形成的复合物具有约 180nm 的粒径和约 75mV 的 zeta 电位，稳定性良好。在不同 TRAIL 敏感性的多种人乳腺癌细胞系中，研究了该药物-蛋白共递药系统的抗癌作用和凋亡途径机制。共递药纳米粒系统在非癌细胞中诱导协同抗癌活性，同时毒性有限。与游离药物和蛋白质制剂相比，这种共递药的一个优势是具有更高的抗癌效果。
