State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China.
Regen Biomater. 2015 Dec;2(4):229-37. doi: 10.1093/rb/rbv019. Epub 2015 Oct 14.
The aim of this study was to achieve on-demand controlled drug release from the dual-drug-loaded poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles electrospun composite fibers by the application of ultrasound irradiation. Two drugs were loaded in different part of the composite fibrous materials, and it was found that ultrasound as an external stimulus was able to control release of drugs due to both its thermal effect and non-thermal effect. With the selective irradiation of ultrasound, the drug carrier enabled to realize controlled release, and because of different location in fibers and sensitivity of two different kinds of drugs to ultrasound irradiation, the release rate of two drugs was different. These results indicated that ultrasound irradiation was a facile method to realize the on-demand controlled release of two drugs from the electrospun fibers.
本研究旨在通过应用超声辐射，从载双药的聚（乳酸-共-乙醇酸）/介孔硅纳米粒子电纺复合纤维中实现按需控制药物释放。两种药物被装载在复合纤维材料的不同部位，研究发现，超声作为一种外部刺激，可以通过其热效应和非热效应来控制药物释放。通过选择性地辐照超声，药物载体能够实现控制释放，并且由于两种不同药物在纤维中的位置不同以及对超声辐射的敏感性不同，两种药物的释放速率也不同。这些结果表明，超声辐射是一种从电纺纤维中实现两种药物按需控制释放的简便方法。
