Department of Dermatology, Hospital General Dr. Manuel Gea González, México City, Mexico.
Int J Dermatol. 2010 Dec;49(12):1376-9. doi: 10.1111/j.1365-4632.2010.04599.x.
The skin wart is a benign proliferation of the skin and mucous, secondary to human papillomavirus (HPV) infection.
The objective of this study is to determine gene frequencies of HLA-DR alleles in Mexican patients with skin warts and compare them with those present in ethnically matched healthy subjects.
Fifty-two patients with clinically and histologically confirmed skin warts from the Dermatology Outpatient Clinic, with results of high-resolution DNA typing for HLA-DR polymorphism.
HLA-DR3 and DR9 were increased (P = 0.0029, OR: 2.5, 95% CI: 1.3–4.7 and P = 0.0062, OR: 5.4, 95% CI: 1.4–19.5, respectively), and HLA-DR6 allele was found decreased (P = 0.0002).
The major histocompatibility complex contribution in the infection and elimination of the virus is not clear and perhaps also contributes to a series of events not well established yet.
This study follows the preponderant role of class II genes in the susceptibility or resistance to the development of skin warts caused by HPV infection.
皮肤疣是皮肤和黏膜的良性增生，继发于人类乳头瘤病毒（HPV）感染。
本研究旨在确定墨西哥皮肤疣患者 HLA-DR 等位基因的基因频率，并与具有匹配种族的健康受试者进行比较。
对来自皮肤科门诊的 52 例经临床和组织学证实的皮肤疣患者进行高分辨率 DNA 分型 HLA-DR 多态性检测。
HLA-DR3 和 DR9 增加（P = 0.0029，OR：2.5，95%CI：1.3-4.7 和 P = 0.0062，OR：5.4，95%CI：1.4-19.5），HLA-DR6 等位基因减少（P = 0.0002）。
主要组织相容性复合体在病毒感染和清除中的作用尚不清楚，也许还与一系列尚未明确的事件有关。
本研究表明，在 HPV 感染引起的皮肤疣发生的易感性或抗性中，II 类基因起主导作用。
