Department of Dermatology, School of Medicine, Hacettepe University, Ankara, Turkey.
Division of Pediatric Immunology, Department of Pediatrics, School of Medicine, Hacettepe University, Ankara, Turkey.
Exp Dermatol. 2021 Nov;30(11):1642-1649. doi: 10.1111/exd.14362. Epub 2021 May 5.
Human leukocyte antigens (HLAs), which are genetic markers that have critical roles in the immune response against pathogens, vary greatly among individuals. The aim of the study is to investigate the frequency of HLA class I (HLA-A, HLA-B and HLAC) and class II (HLA-DRB1, HLA-DQB1 and HLA-DQA1) genes in patients with multiple skin warts and to elucidate the role of these genes in the genetic susceptibility to skin warts. Peripheral venous blood samples were collected from 100 patients with multiple skin warts and 300 healthy individuals (controls). HLA typing was performed after DNA isolation from the blood samples. The HLA-A02 (odds ratio [OR]: 0.12; p = 0.0019), HLA-DQA103:01 (OR: 0.45; p = 0.0017) and DQA105:01 (OR: 0.17; p < 0.0001) genes were significantly more prevalent in the patients than in the healthy individuals and were thus identified as risk genes. The HLA-DQA101:01 (OR: 0.17; p < 0.0001), HLA-DQA101:02 (OR: 0.17; p < 0.0001), HLA-DQA101:03 (OR: 0.11; p < 0.0001), HLA-DQA102:01 (OR:027; p<0.0001) and HLA-DQA105:05 (OR:0.16; p<0.0001) genes were classified as protective genes because of their low frequencies in the patients. The limitation of the study is that Human papillomavirus typing could not be performed while investigating the relationship between skin warts and HLA class I and class II genes. Our data suggest the role of HLA genes in the development of skin warts. However, other components of the major histocompatibility complex system and acquired factors of the immune system could also be involved and should be further investigated.
人类白细胞抗原（HLA）是在对抗病原体的免疫反应中起关键作用的遗传标记，个体之间差异很大。本研究旨在探讨多发性皮肤疣患者 HLA Ⅰ类（HLA-A、HLA-B 和 HLA-C）和Ⅱ类（HLA-DRB1、HLA-DQB1 和 HLA-DQA1）基因的频率，并阐明这些基因在皮肤疣遗传易感性中的作用。采集 100 例多发性皮肤疣患者和 300 例健康个体（对照组）的外周静脉血样，从血样中提取 DNA 后进行 HLA 分型。HLA-A02（比值比 [OR]：0.12；p=0.0019）、HLA-DQA103:01（OR：0.45；p=0.0017）和 DQA105:01（OR：0.17；p<0.0001）基因在患者中明显更为常见，因此被鉴定为风险基因。HLA-DQA101:01（OR：0.17；p<0.0001）、HLA-DQA101:02（OR：0.17；p<0.0001）、HLA-DQA101:03（OR：0.11；p<0.0001）、HLA-DQA102:01（OR：027；p<0.0001）和 HLA-DQA105:05（OR：0.16；p<0.0001）基因因在患者中频率较低而被归类为保护基因。本研究的局限性在于，在研究皮肤疣与 HLA Ⅰ类和Ⅱ类基因之间的关系时，无法进行人类乳头瘤病毒分型。我们的数据表明 HLA 基因在皮肤疣的发生发展中起作用。然而，主要组织相容性复合体系统的其他成分和免疫系统的获得性因素也可能参与其中，应进一步研究。
