Grint Nicola J, Alderson Briony, Dugdale Alexandra H A
Department of Veterinary Clinical Science, School of Veterinary Science, University of Liverpool, Leahurst, Neston, Wirral, CH46 7TE, England.
J Am Vet Med Assoc. 2010 Dec 15;237(12):1431-7. doi: 10.2460/javma.237.12.1431.
To assess sedative and cardiopulmonary effects of premedication with a medetomidine-buprenorphine or acepromazine-buprenorphine combination in dogs anesthetized with propofol and isoflurane.
Randomized controlled clinical trial.
90 dogs undergoing routine surgical and diagnostic procedures.
Dogs were randomly assigned to 1 of 3 premedication groups: group 1 (acepromazine, 0.03 mg/kg [0.014 mg/lb], IM; buprenorphine, 0.02 mg/kg [0.009 mg/lb], IM), 2 (medetomidine, 5 μg/kg [2.3 μg/lb], IM; buprenorphine, 0.02 mg/kg, IM), or 3 (medetomidine, 10 μg/kg [4.5 μg/lb], IM; buprenorphine, 0.02 mg/kg, IM). Anesthesia was induced with propofol and maintained with isoflurane in oxygen. Simple descriptive scores for sedation were assigned 15 minutes (groups 2 and 3) and 30 minutes (group 1) after premedication administration. Basic cardiopulmonary data were recorded throughout the anesthetic period. Times to recovery from anesthesia were recorded.
Sedation scores did not differ significantly among groups. Mean and diastolic blood pressures were significantly lower and heart rate was significantly higher in group 1 than in the other groups. Mean end-tidal partial pressure of CO(2) was significantly lower and respiratory rate was significantly higher in group 1 than in the other groups. There were no significant differences in anesthetic recovery times between groups.
Results suggested that either acepromazine or medetomidine could be used in combination with buprenorphine for premedication of dogs anesthetized with propofol and isoflurane for routine surgical and diagnostic procedures. Arterial blood pressure was better maintained with the medetomidine-buprenorphine combinations, but tissue perfusion was not investigated.
评估在接受丙泊酚和异氟烷麻醉的犬中，使用美托咪定-丁丙诺啡或乙酰丙嗪-丁丙诺啡联合用药进行术前用药的镇静及心肺效应。
随机对照临床试验。
90只接受常规外科手术和诊断程序的犬。
犬被随机分配至3个术前用药组中的1组：第1组（乙酰丙嗪，0.03 mg/kg [0.014 mg/磅]，肌肉注射；丁丙诺啡，0.02 mg/kg [0.009 mg/磅]，肌肉注射），第2组（美托咪定，5 μg/kg [2.3 μg/磅]，肌肉注射；丁丙诺啡，0.02 mg/kg，肌肉注射），或第3组（美托咪定，10 μg/kg [4.5 μg/磅]，肌肉注射；丁丙诺啡，0.02 mg/kg，肌肉注射）。用丙泊酚诱导麻醉，并用异氟烷和氧气维持麻醉。在术前用药给药后15分钟（第2组和第3组）和30分钟（第1组）进行简单的镇静描述评分。在整个麻醉期间记录基本的心肺数据。记录麻醉苏醒时间。
各组间镇静评分无显著差异。第1组的平均血压和舒张压显著低于其他组，心率显著高于其他组。第1组的平均呼气末二氧化碳分压显著低于其他组，呼吸频率显著高于其他组。各组间麻醉苏醒时间无显著差异。
结果表明，乙酰丙嗪或美托咪定均可与丁丙诺啡联合用于接受丙泊酚和异氟烷麻醉的犬的术前用药，以进行常规外科手术和诊断程序。美托咪定-丁丙诺啡联合用药能更好地维持动脉血压，但未对组织灌注进行研究。
