Department of Emergency and Organ Transplantation, Division of Veterinary Clinics and Animal Productions, University of Bari Aldo Moro, Str. Provinciale, Valenzano-Casamassima km. 3, 70010 - Valenzano, Bari, Italy.
Res Vet Sci. 2013 Oct;95(2):687-92. doi: 10.1016/j.rvsc.2013.03.022. Epub 2013 May 2.
The aim of this study was to compare the cardiovascular effects of medetomidine, acepromazine and their combination administered intravenously in healthy dogs. Ten dogs were included in this study and randomly assigned to the three different sedative protocols: medetomidine (2 μg/kg, protocol M), acepromazine (20 μg/kg, protocol A) and acepromazine followed by medetomidine with the same doses as above (protocol AM), in three different times. In all subjects before (Tbase) and 15 (T15), 50 (T50) and 80 (T80) minutes after the administration of the drugs, the following non-invasive measurements were obtained: blood pressure with oscillometric method, ECG, and echocardiography. Blood pressure and echocardiography evidenced decrease in left ventricular afterload secondary to acepromazine and an increase in right ventricular afterload due to medetomidine. The combination of the two drugs mitigated the effects expected by the single drugs used alone, and prevented the onset of atrioventricular blocks, such as seen in protocol M. The three protocols were eligible for sedation and premedication in healthy dogs. Moreover they had little impact on the echocardiographic variables evaluated in this study.
本研究旨在比较静脉注射咪达唑仑、乙酰丙嗪及其联合用药对健康犬的心血管效应。本研究纳入 10 只犬，随机分为三组镇静方案：咪达唑仑（2μg/kg，方案 M）、乙酰丙嗪（20μg/kg，方案 A）和乙酰丙嗪后给予相同剂量的咪达唑仑（方案 AM）。在所有研究对象中，在药物给药前（Tbase）和给药后 15 分钟（T15）、50 分钟（T50）和 80 分钟（T80），进行以下非侵入性测量：使用振荡法测量血压、心电图和超声心动图。血压和超声心动图结果显示，乙酰丙嗪可降低左心室后负荷，而咪达唑仑可增加右心室后负荷。两种药物联合使用可减轻单独使用单一药物时的预期作用，并可预防房室传导阻滞的发生，如方案 M 中所见。三种方案均可用于健康犬的镇静和术前用药。此外，它们对本研究评估的超声心动图变量几乎没有影响。
