Department of Radiation Oncology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Expert Rev Pharmacoecon Outcomes Res. 2010 Dec;10(6):667-76. doi: 10.1586/erp.10.81.
Lung cancer is a leading cause of cancer deaths for both men and women across the world. In the past, studies on lung cancer have focused on traditional end points such as survival, disease-free survival or local control. More recently, investigators have begun to appreciate the importance of health-related quality-of-life outcomes, particularly in the setting of lung cancer. This article provides an overview of the importance, methodology, analysis and presentation of health-related quality of life in lung cancer trials, and also discusses some of the limitations and challenges of such studies.
肺癌是全世界男性和女性癌症死亡的主要原因。过去，肺癌的研究主要集中在传统终点，如生存、无病生存或局部控制。最近，研究人员开始认识到健康相关生活质量结局的重要性，特别是在肺癌的背景下。本文概述了肺癌临床试验中健康相关生活质量的重要性、方法学、分析和报告，并讨论了此类研究的一些局限性和挑战。
