诱饵受体 3 在食管鳞癌中的表达：与肿瘤侵袭和转移的相关性。
Decoy receptor 3 expression in esophageal squamous cell carcinoma: correlation with tumour invasion and metastasis.
机构信息
Department of Thoracic and Cardiac Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China.
出版信息
Biomarkers. 2011 Mar;16(2):155-60. doi: 10.3109/1354750X.2010.536258. Epub 2010 Dec 15.
OBJECTIVE
Decoy receptor 3 (DcR3) is a soluble receptor, which can bind to and inactivate the apoptosis-inducing ligands. We studied a possible association between DcR3 expression and clinicopathologic features in patients with esophageal squamous cell carcinoma (ESCC).
METHODS
The mRNA expression of DcR3 was examined by RT-PCR in 109 primary ESCC patients. For the 52 pairs of DcR3 positive tissues, the protein expression was determined by immunohistochemistry.
RESULTS
There was a strong correlation among DcR3 mRNA expression and tumor invasion (P=0.01) and lymph node metastasis (P=0.036). We also found that there was a correlation between DcR3 overexpression with lymph node metastasis (P=0.014) in 52 pairs of DCR3 mRNA positive tissues.
CONCLUSIONS
Our finding suggested that the overexpression of DcR3 is significantly related with ESCC clinical staging. DcR3 might be a candidate as a tumor specific biomarker for ESCC.
目的
诱饵受体 3（DcR3）是一种可溶性受体，可与凋亡诱导配体结合并使其失活。我们研究了 DcR3 表达与食管鳞癌（ESCC）患者临床病理特征之间的可能关联。
方法
采用 RT-PCR 检测 109 例原发性 ESCC 患者中 DcR3 的 mRNA 表达。对于 52 对 DcR3 阳性组织，采用免疫组织化学法检测蛋白表达。
结果
DcR3mRNA 表达与肿瘤侵袭（P=0.01）和淋巴结转移（P=0.036）之间存在很强的相关性。我们还发现，在 52 对 DCR3mRNA 阳性组织中，DcR3 过表达与淋巴结转移（P=0.014）之间存在相关性。
结论
我们的研究结果表明，DcR3 的过表达与 ESCC 的临床分期显著相关。DcR3 可能是 ESCC 的肿瘤特异性生物标志物候选者。
Zotero 插件