山莨菪碱对急性呼吸窘迫综合征（ARDS）防治作用的实验研究
[Experimental research of prevention and therapy effect of anisodamine on acute respiratory distress syndrome (ARDS)].
作者信息
Jing You-Ling, Wang Yan-Lei, Sun Ying, Zhao Chun-Xiu, Li Hong-Jie, Kong Xiao-Yan
机构信息
North Coal Medical College, Tangshan 063000, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009 Nov;25(4):557-60.
AIM
To study preventive and therapeutic effect of anisodamine on acute respiratory distress syndrome(ARDS) induced by oleic acid and their mechanism of action.
METHODS
Model of ARDS was made in rabbits by oleic acid (OA). The effect of anisodamine on the malondialdehyde (MDA), fibronectin (FN), lactate dehydrogenase (LDH) and acid phosphatase (ACP) in plasma, and superoxide dismutase (SOD) in erythrocyte and MDA, SOD and pulmonary surfactant (PS) in lung tissues homogenate and pathological examination of lung were observed.
RESULTS
The administration of anisodamine before and after 30 minutes of injection OA decreased MDA, LDH and ACP, prevented the reduction of SOD, FN and PS. Compared with ARDS group, there was marked difference between the two, and alleviated lung injury.
CONCLUSION
Anisodamine possesses preventive and therapeutic effects on ARDS by inhibiting lipid peroxidation and stabilizing membranes.
目的
研究山莨菪碱对油酸诱导的急性呼吸窘迫综合征（ARDS）的防治作用及其作用机制。
方法
采用油酸（OA）制备兔ARDS模型。观察山莨菪碱对血浆中丙二醛（MDA）、纤维连接蛋白（FN）、乳酸脱氢酶（LDH）和酸性磷酸酶（ACP），红细胞中超氧化物歧化酶（SOD），肺组织匀浆中MDA、SOD和肺表面活性物质（PS）的影响以及肺组织病理检查结果。
结果
在注射OA前及注射后30分钟给予山莨菪碱，可降低MDA、LDH和ACP水平，防止SOD、FN和PS水平降低。与ARDS组相比，二者差异显著，且减轻了肺损伤。
结论
山莨菪碱通过抑制脂质过氧化和稳定细胞膜对ARDS具有防治作用。
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