Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Curr Eye Res. 2011 Feb;36(2):125-34. doi: 10.3109/02713683.2010.533807. Epub 2010 Dec 15.
To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral and time domain optical coherence tomography (OCT).
One hundred and eighty-eight subjects (normal tension glaucoma, n = 80; primary open angle glaucoma, n = 49; healthy controls, n = 59) were included in this study. Peripapillary RNFL thickness was measured by an Optic Disc Cube 200 × 200 scan of the spectral domain Cirrus HD OCT and by a Fast RNFL scan of the time domain Stratus OCT. They were compared using linear regression (R(2)), Bland-Altman plots, weighted Kappa (K(w)) coefficients, and areas under the receiver operating characteristic curve (AROC).
Except for the inferior quadrant, RNFL thickness measurements by Cirrus HD OCT were thinner than Stratus OCT (all p < 0.001); for the inferior quadrant, this tendency was vice versa (p = 0.043). Average RNFL thicknesses of the two OCTs showed a good correlation (R(2), 0.852) but not excellent agreement (mean of difference, 4.0 μm; +1.96 SD, 10.7 μm; -1.96 SD, -18.6 μm). Regarding the probability codes, only the average RNFL thickness had almost perfect agreement (K(w), 0.983). In addition, Cirrus HD OCT had the largest AROC for the superior quadrant (0.795), but Stratus OCT had the largest AROC for average RNFL thickness (0.764) (p = 0.281).
Except for the inferior quadrant, the average and quadrants RNFL thickness measured by the Cirrus HD OCT were thinner than the Stratus OCT. Regarding discriminating power for glaucoma detection, the Cirrus HD OCT was better than the Stratus OCT for the superior and inferior quadrant RNFL thicknesses but not for the average RNFL thickness.
比较频域和时域光学相干断层扫描（OCT）测量的视盘周围视网膜神经纤维层（RNFL）厚度。
本研究纳入 188 名受试者（正常眼压性青光眼，n=80；原发性开角型青光眼，n=49；健康对照者，n=59）。采用光谱域 Cirrus HD OCT 的 Optic Disc Cube 200×200 扫描和时域 Stratus OCT 的 Fast RNFL 扫描测量视盘周围 RNFL 厚度。采用线性回归（R(2)）、Bland-Altman 图、加权 Kappa（K(w)）系数和受试者工作特征曲线下面积（AUC）比较两种 OCT 的测量结果。
除了下方象限，Cirrus HD OCT 测量的 RNFL 厚度均较 Stratus OCT 薄（均 P<0.001）；下方象限则相反（P=0.043）。两种 OCT 平均 RNFL 厚度具有良好的相关性（R(2)，0.852），但一致性不佳（差值均值，4.0 μm；+1.96 SD，10.7 μm；-1.96 SD，-18.6 μm）。关于概率编码，只有平均 RNFL 厚度具有近乎完美的一致性（K(w)，0.983）。此外，Cirrus HD OCT 对上方象限的 AUC 最大（0.795），但 Stratus OCT 对平均 RNFL 厚度的 AUC 最大（0.764）（P=0.281）。
除了下方象限，Cirrus HD OCT 测量的平均和各象限 RNFL 厚度均较 Stratus OCT 薄。在区分青光眼检测能力方面，Cirrus HD OCT 对上方和下方象限的 RNFL 厚度优于 Stratus OCT，但对平均 RNFL 厚度则不然。
