Department of Hematology, The affiliated Zhongda Hospital, Southeast University, Nanjing 210009, P.R China.
Curr Cancer Drug Targets. 2011 Feb;11(2):184-9. doi: 10.2174/156800911794328475.
Magnetic nanoparticles have been intensively investigated due to their magnetic characteristics, quantum dot effects, as well as their potential applications in the area of bioscience and medicine. Very promising nanoparticles are magnetic iron oxide nanoparticles with appropriate surface modification which have been widely used experimentally for masses of in vivo applications such as magnetic resonance imaging contrast enhancement, drug delivery, and hyperthermia, etc.. All these biomedical applications require that these nanoparticles have effective magnetic values and suitable sizes. On the other hand, these applications need special surface modification of these particles, which not only have to be non-toxic and biocompatible, but also allow a targetable drug delivery in a specific area. This review summarizes the current research situation and development of magnetic iron oxide nanoparticles, and the biomedical applications ranging from drug delivery to hyperthermia for tumor-targeted therapy.
由于其磁性特性、量子点效应以及在生物科学和医学领域的潜在应用，磁性纳米粒子受到了广泛关注。具有适当表面修饰的磁性氧化铁纳米粒子是非常有前途的纳米粒子，已经广泛应用于大量的体内应用，如磁共振成像对比增强、药物输送和热疗等。所有这些生物医学应用都要求这些纳米粒子具有有效的磁性能和合适的尺寸。另一方面，这些应用需要对这些粒子进行特殊的表面修饰，不仅要无毒、生物相容，还要能够在特定区域靶向药物输送。本文综述了磁性氧化铁纳米粒子的研究现状和发展，以及从药物输送到肿瘤靶向热疗的生物医学应用。
