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利用磁力进行癌症治疗的纳米颗粒。

Nanoparticles for cancer therapy using magnetic forces.

机构信息

Department of Oto-rhino-laryngology, Head & Neck Surgery, Erlangen University Hospital, Section for Experimental Oncology & Nanomedicine (Else Kröner-Fresenius-Stiftungsprofessur), Glückstrasse 10, 91054 Erlangen, Germany.

出版信息

Nanomedicine (Lond). 2012 Mar;7(3):447-57. doi: 10.2217/nnm.12.10.

Abstract

The term 'nanomedicine' refers to the use of nanotechnology in the treatment, diagnosis and monitoring of diseases. Magnetic drug targeting is a particularly promising application in this field. The goal of the carrier systems involved is to achieve active enrichment of effective substances in diseased tissue. Numerous nanosystems can be used as carriers, but magnetic iron oxide nanoparticles are particularly important. On the one hand, the particles serve as carriers for the active substance, while on the other hand they can also be visualized using conventional imaging techniques and can therefore be used for 'theranostic' purposes. They can also be used in hyperthermia, another important pillar of nanomedicine. Both procedures are intended to lead to specific forms of treatment, which is of medical and economic relevance in view of the increasing numbers of cancer patients worldwide. This study offers a brief overview of current developments in medical applications for magnetic nanoparticles in cancer therapy.

摘要

“纳米医学”是指在疾病的治疗、诊断和监测中使用纳米技术。磁靶向药物输送是该领域中一个特别有前途的应用。所涉及的载体系统的目标是实现有效物质在病变组织中的主动富集。有许多纳米系统可用作载体,但磁性氧化铁纳米颗粒尤为重要。一方面,这些颗粒可用作活性物质的载体,另一方面,它们也可以使用常规成像技术进行可视化,因此可用于“治疗诊断”目的。它们还可用于另一种重要的纳米医学手段——热疗。这两种方法都旨在实现特定形式的治疗,鉴于全球癌症患者人数的不断增加,这在医学和经济上都具有重要意义。本研究简要概述了磁性纳米粒子在癌症治疗中的医学应用的最新进展。

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