Khatri Rakesh, Miley Jefferson T, Qureshi Adnan I
Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
J Neuroimaging. 2013 Jul;23(3):317-8. doi: 10.1111/j.1552-6569.2010.00563.x.
Time window for thrombolysis in acute ischemic stroke can be based on chronological or physiological (imaging) data. Both of these approaches have their unique strengths and weaknesses. The concept of chronological-based thrombolysis is supported by several randomized clinical trials whereas imaging-based thrombolysis has not been validated entirely by randomized trials. Therefore, careful evaluation of strategies using image-based identification of patients who might benefit from thrombolysis is needed. Patients undergoing thrombolysis on delayed arrival appear to be the most logical group in whom image-based strategies should be evaluated.
急性缺血性卒中溶栓的时间窗可基于时间顺序或生理学（影像学）数据。这两种方法都有其独特的优势和劣势。基于时间顺序的溶栓概念得到了多项随机临床试验的支持，而基于影像学的溶栓尚未完全通过随机试验得到验证。因此，需要仔细评估使用基于影像学识别可能从溶栓中获益患者的策略。延迟就诊时接受溶栓的患者似乎是最适合评估基于影像学策略的合理人群。
