Sawangsang Pitkanya, Sae-Teng Charuwan, Suprasert Prapaporn, Srisomboon Jatupol, Khunamornpong Surapan, Kietpeerakool Chumnan
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
J Obstet Gynaecol Res. 2011 Jun;37(6):496-500. doi: 10.1111/j.1447-0756.2010.01387.x. Epub 2010 Dec 15.
To evaluate the histopathology of women who had atypical glandular cells (AGC) on Pap smears in a region with high incidence of cervical cancer.
This study was conducted at Chiang Mai University Hospital, Chiang Mai, Thailand. All women with AGC who underwent colposcopic and histopathologic evaluation between January 2002 and December 2008 were reviewed. Women with simultaneous diagnosis of squamous cell abnormality or prior history of cancer of any type were excluded.
Sixty-three women with AGC Pap test had histologic follow-up during the study period. Mean age was 44.9 years (range, 31-72 years). Six (9.5%) women were nulliparous. Sixteen (25.4%) women were postmenopausal. The histopathologic results of these 63 women were as follows: cervical intraepithelial neoplasia (CIN) 2-3, 5 (7.9%); adenocarcinoma in situ (AIS), 3 (4.8%); endometrial cancer, 3 (4.8%); cervical cancer, 2 (3.2%); endometrial hyperplasia (EH), 1 (1.6%); and no lesions, 49 (77.8%). The prevalence of significant lesions (CIN 2-3, AIS, EH, and cancer) in women with atypical glandular cells, favor neoplasia (AGC-FN) was significantly higher than that in the atypical glandular cells, not other specified (AGC-NOS) group (41.2% and 15.2%, P = 0.02).
Reporting AGC in our population is clinically significant due to the high prevalence of underlying preinvasive and invasive diseases (22.2%). This subtype of the AGC category is a significant predictor of such lesions.
评估在宫颈癌高发地区巴氏涂片检查出现非典型腺细胞（AGC）的女性的组织病理学情况。
本研究在泰国清迈的清迈大学医院开展。回顾了2002年1月至2008年12月期间所有接受阴道镜检查和组织病理学评估的AGC女性。排除同时诊断为鳞状细胞异常或有任何类型癌症既往史的女性。
在研究期间，63例AGC巴氏试验女性接受了组织学随访。平均年龄为44.9岁（范围31 - 72岁）。6例（9.5%）女性未生育。16例（25.4%）女性绝经。这63例女性的组织病理学结果如下：宫颈上皮内瘤变（CIN）2 - 3级，5例（7.9%）；原位腺癌（AIS），3例（4.8%）；子宫内膜癌，3例（4.8%）；宫颈癌，2例（3.2%）；子宫内膜增生（EH），1例（1.6%）；无病变，49例（77.8%）。非典型腺细胞倾向肿瘤（AGC - FN）女性中显著病变（CIN 2 - 3级、AIS、EH和癌症）的患病率显著高于非典型腺细胞未另行指定（AGC - NOS）组（41.2%和15.2%，P = 0.02）。
在我们的人群中报告AGC具有临床意义，因为潜在的癌前和浸润性疾病患病率较高（22.2%）。AGC类别的这种亚型是此类病变的重要预测指标。
