Ulker V, Numanoglu C, Akyol A, Kuru O, Akbayir O, Erim A, Ongut C
Department of Obstetrics and Gynecology, Oncology Unit, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Kanuni Sultan Siileyman Training and Research Hospital, Istanbul, Turkey.
Eur J Gynaecol Oncol. 2013;34(5):457-61.
To evaluate the histopathology and the long-term follow-up outcome of women who had atypical glandular cells on Pap smears.
All women with atypical glandular cells (AGC) who underwent colposcopic and histopathologic evaluation between January 2005 and October 2010 were reviewed. Patient data were examined up to October 2012, allowing for at least two years of follow-up for all patients.
Forty-four women with AGC Pap test underwent histologic follow-up during the study period. Overall, upon reclassification of smears, 35 (79.5%) cases were diagnosed with AGC "not otherwise specified" (NOS) and nine (20.5%) with AGC "favour neoplasia". Seven out of nine patients (77.7%) with AGC "favour neoplasia" had significant pathology. On the other hand, only 11 out of 35 cases (31.4%) with AGC "NOS" had significant pathology. Significant correlation was found between AGC "favour neoplasia" smears and a significant pathology (p: 0.01). Of the 44 patients, 18 (40.9%) had significant pathology. Eight patients (18.2%) had low grade cervical intraepithelial neoplasia (CIN 1), four (9%) had high-grade cervical intraepithelial neoplasia (CIN 2/3), one (2.2%) had microinvasive squamous cell carcinoma of uterine cervix, one (2.2%) had cervical adenocarcinoma in situ, one (2.2%) had cervical adenocarcinoma, one (2.2%) had endometrial adenocarcinoma, and two (4.5%) had endometrial hyperplasia.
Reporting AGC in the population is clinically significant due to the high prevalence of underlying preinvasive and invasive diseases (40.9%). The subtypes of the AGC category are significant predictor of such lesions.
评估巴氏涂片检查出现非典型腺细胞的女性的组织病理学及长期随访结果。
回顾了2005年1月至2010年10月间所有接受阴道镜及组织病理学评估的非典型腺细胞（AGC）女性患者。对患者数据随访至2012年10月，所有患者至少随访两年。
在研究期间，44例巴氏试验显示AGC的女性接受了组织学随访。总体而言，重新分类涂片后，35例（79.5%）诊断为AGC“未另行指定”（NOS），9例（20.5%）诊断为AGC“倾向肿瘤”。9例AGC“倾向肿瘤”患者中有7例（77.7%）存在显著病理改变。另一方面，35例AGC“NOS”患者中只有11例（31.4%）存在显著病理改变。AGC“倾向肿瘤”涂片与显著病理改变之间存在显著相关性（p：0.01）。44例患者中，18例（40.9%）存在显著病理改变。8例（18.2%）患有低级别宫颈上皮内瘤变（CIN 1），4例（9%）患有高级别宫颈上皮内瘤变（CIN 2/3），1例（2.2%）患有宫颈微浸润鳞状细胞癌，1例（2.2%）患有宫颈原位腺癌，1例（2.2%）患有宫颈腺癌，1例（2.2%）患有子宫内膜腺癌，2例（4.5%）患有子宫内膜增生。
由于潜在的浸润前和浸润性疾病患病率较高（40.9%），在人群中报告AGC具有临床意义。AGC类别的亚型是此类病变的重要预测指标。
