Galimberti G, Pontón Montaño A, Ferrario D, Kowalczuk A, Galimberti R
Servicio de Dermatología, Escuela de Medicina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Actas Dermosifiliogr. 2010 Dec;101(10):853-7.
Basal cell carcinoma accounts for 75% of all nonmelanoma skin cancer. Although various treatment modalities are available, the most frequently used option is surgical excision. Here, we evaluate the efficacy of Mohs micrographic surgery for the treatment of basal cell carcinoma.
A retrospective review of cases of basal cell carcinoma treated with Mohs micrographic surgery between October 2003 and June 2009 was performed using patient records from Hospital Italiano in Buenos Aires, Argentina.
A total of 2412 basal cell carcinomas treated with Mohs micrographic surgery were identified; 50.5% were in women and 49.5% in men. The mean age of the patients was 70.7 years (range, 8-100 years). The histologic type of the tumor was solid in 65.3% of cases and in 89% of cases the tumor was located on the head or neck. Ten percent of the tumors were recurrent following previous treatment. A mean of 1.74 Mohs stages were used, with a mean of 3.81 sections. The mean size of the initial defect was 0.86 cm² and the mean final defect was 1.88 cm². The ratio of initial tumor size to final defect was estimated at 1.02. Over a mean follow-up of 32 months, there were 9 cases of tumor recurrence (0.37%).
In our experience, Mohs micrographic surgery is effective for the treatment of high-risk basal cell carcinoma.
基底细胞癌占所有非黑色素瘤皮肤癌的75%。尽管有多种治疗方式可供选择，但最常用的方法是手术切除。在此，我们评估莫氏显微外科手术治疗基底细胞癌的疗效。
使用阿根廷布宜诺斯艾利斯意大利医院的患者记录，对2003年10月至2009年6月间接受莫氏显微外科手术治疗的基底细胞癌病例进行回顾性研究。
共确定2412例接受莫氏显微外科手术治疗的基底细胞癌；其中女性占50.5%，男性占49.5%。患者的平均年龄为70.7岁（范围为8 - 100岁）。65.3%的病例肿瘤组织学类型为实性，89%的病例肿瘤位于头颈部。10%的肿瘤为先前治疗后复发。平均使用1.74个莫氏分期，平均切片3.81张。初始缺损的平均大小为0.86平方厘米，最终缺损的平均大小为1.88平方厘米。初始肿瘤大小与最终缺损的比例估计为1.02。平均随访32个月，有9例肿瘤复发（0.37%）。
根据我们的经验，莫氏显微外科手术治疗高危基底细胞癌有效。
