Department of Obstetrics and Gynecology, University of Freiburg School of Medicine, 79106 Freiburg, Germany.
Gynecol Oncol. 2011 Apr;121(1):169-73. doi: 10.1016/j.ygyno.2010.11.024. Epub 2010 Dec 14.
Recent evidence suggests equivalent efficacy in terms of local control for adjuvant vaginal brachytherapy (VBT) compared to external beam radiotherapy after surgery in patients with intermediate-high endometrial cancer. The objective of this study is to compare the quality of life (QoL) and sexual function of women with endometrial cancer that were treated with either surgery alone or surgery in combination with postoperative VBT.
Women were interviewed at least 5 years after initial treatment for endometrial cancer. QoL was evaluated by using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and the cervical cancer module, CX-24. Sexual function was evaluated by using the Female Sexual Function Index (FSFI). Eligible women had early stage disease, were currently disease-free, and had undergone surgery and adjuvant VBT, but neither external beam radiotherapy nor systemic treatment. This study group were then compared using univariate and multivariate analyses with an age-matched control group comprising of endometrial cancer patients without adjuvant VBT.
Fifty-five patients (29 surgery plus VBT and 26 surgical controls without VBT) were included for analysis. With respect to QoL including, e.g., physical, role, emotional and social functioning and likewise in terms of sexual function univariate and multivariate analyses did not show significant differences between patients with VBT and the controls without VBT of any of the outcome measures.
Adjuvant VBT after surgery does not seem to have a significant impact on quality of life and sexual function in endometrial cancer survivors.
最近的证据表明，在中高危子宫内膜癌患者中，与手术后外照射放疗相比，辅助阴道近距离放疗（VBT）在局部控制方面具有等效疗效。本研究的目的是比较单独手术或手术后联合术后 VBT 治疗的子宫内膜癌女性的生活质量（QoL）和性功能。
在初始子宫内膜癌治疗后至少 5 年，对女性进行访谈。通过欧洲癌症研究与治疗组织生活质量问卷 C30 和宫颈癌模块 CX-24 评估 QoL。通过女性性功能指数（FSFI）评估性功能。符合条件的女性患有早期疾病，目前无疾病，接受了手术和辅助 VBT，但未接受外照射放疗或全身治疗。然后，使用单变量和多变量分析，将这组患者与未接受辅助 VBT 的年龄匹配的子宫内膜癌患者对照组进行比较。
55 名患者（29 名手术加 VBT 和 26 名手术对照组无 VBT）纳入分析。关于 QoL，包括身体、角色、情感和社会功能，以及性功能，单变量和多变量分析均未显示 VBT 患者与无 VBT 对照组在任何结果测量上存在显著差异。
手术后辅助 VBT 似乎不会对子宫内膜癌幸存者的生活质量和性功能产生重大影响。
